A 3-D optical imaging system based on active stereo vision and motion tracking is built to track the motion of patient and to register the time-sequenced images of cervix recorded during colposcopy. The imaging system is evaluated by examining human subjects in vivo before routine colposcopy examination procedures. The system tracks the motion of patient accurately. The temporal kinetics of the...

The Papanicolaou smear remains the most common method for the detection of precancerous changes in cervical cytology. However, the introduction of a liquid-based cytology (LBC) technique expands the possibility of cervical intraepithelial neoplasia (CIN) diagnosis, and permits detection of precancerous changes and human papillomavirus (HPV) simultaneously. In the pilot study reported here, usin...

Similarities in gene expression between both developing embryonic and precancerous tissues and cancer tissues may help identify much-needed biomarkers and therapeutic targets in lung squamous carcinoma. In this study, human lung samples representing ten successive time points, from embryonic development to carcinogenesis, were used to construct global gene expression profiles. Differentially ex...

An exact classification of precancerous stages of colorectal polyps might improve therapy and patients´ outcome. Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. A reproducible staining procedure for histologic MMP-13 analysis in routinely fixed c...

Background and Aim: Oral lichen planus (OLP) is a chronic mucocutaneous disease, which is considered a precancerous condition. OLP is a multifactorial disease with no conclusive treatment. Timely diagnosis and treatment of oral lesions are necessary steps to prevent malignant transformations and severe complications of oral cancer. This study aimed to evaluate the frequency and severity of mali...

Oral squamous cell carcinomas develop in precancerous fields consisting of genetically altered mucosal epithelial cells. These precancerous fields may appear as clinically visible lesions, in particular, oral leukoplakia, but the large majority remains clinically undetectable. The aim of this study was to assess the potential value of a noninvasive screening approach to detect precancerous fiel...

Background: The most common histologic type of cervical cancer is squamous cell carcinoma (SCC), with the risk recurrence depending on immune surveillance granzyme-B markers, and tumor infiltrating lymphocytes (TIL) an immunological determinant associated a better prognosis. Granzyme-B produced by TIL. study was aimed to prove difference in expression SCC epithelial cells dysplasia precancerous...

BACKGROUND Although mechanisms for detection of short-term complications after blood transfusions are well developed, complications with delayed onset, notably transmission of chronic diseases such as cancer, have been difficult to assess. Our aim was to investigate the possible risk of cancer transmission from blood donors to recipients through blood transfusion. METHODS We did a register-ba...

Objective Cervical cancer (CC) screening by Pap smears has led to a decrease in the incidence of CC worldwide. Indeed, the incidence of CC in Switzerland is very low; however, there is a lack of data to evaluate the efficiency of the Pap smear as a screening tool. Until now, only Pap smears have been used and other methods such as the presence of an infection with HPV have not been integrated i...

We obtained seven monoclonal antibodies (MAb) against a gastric mucin of an ALeb patient. By immunoperoxidase on normal gastric mucosae, two MAbs (3-3A and 2-25 LE) reacted exclusively with the A and Lewis-positive individuals, respectively; the five other MAbs (1-13 M1, 2-11 M1, 2-12 M1, 9-13 M1, and 58 M1) stained the mucus cells of surface gastric epithelium independently of ABO or Lewis sta...