نتایج جستجو برای: precursor cell lymphoblastic leukemia

تعداد نتایج: 1812682  

Journal: :Hematology/oncology clinics of North America 2009
Mihaela Onciu

Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms. Current intensive chemotherapy regimens have acc...

Journal: :Haematologica 2010
Ester Mejstrikova Jana Volejnikova Eva Fronkova Katerina Zdrahalova Tomas Kalina Jaroslav Sterba Yahia Jabali Vladimir Mihal Bohumir Blazek Zdena Cerna Daniela Prochazkova Jiri Hak Zuzana Zemanova Marie Jarosova Alexandra Oltova Petr Sedlacek Jiri Schwarz Jan Zuna Jan Trka Jan Stary Ondrej Hrusak

BACKGROUND Mixed phenotype acute leukemia (MPAL) represents a diagnostic and therapeutic dilemma. The European Group for the Immunological Classification of Leukemias (EGIL) scoring system unambiguously defines MPAL expressing aberrant lineage markers. Discussions surrounding it have focused on scoring details, and information is limited regarding its biological, clinical and prognostic signifi...

Journal: :Frontiers in Pediatrics 2023

Background CD34 + CD38 − lymphoblasts as likely leukemia stem cells (LSCs) may be responsible for a worse response to treatment and risk factor recurrence in B-cell precursor acute lymphoblastic (BCP-ALL). Objective The study objective was assess the prognostic role of bone marrow on day BCP-ALL diagnosis. Methods 115 patients with BCP-ALL, median age 4.5 years (range 1.5–17.9 years), gender: f...

Journal: :Frontiers of Medicine 2021

Abstract B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations with high heterogeneity. Precise subtypes distinct genomic and/or gene expression patterns have been recently revealed using high-throughput sequencing technology. Most of these profiles are associated recurrent non-overlapping rearrangements or hotspot point mutations that analogous to the ...

Journal: :AJNR. American journal of neuroradiology 2003
Christina Thuerl Klaus Müller Jörg Laubenberger Benedikt Volk Mathias Langer

We report the case of a 26-year-old man with precursor T-cell acute lymphoblastic leukemia who developed paraneoplastic limbic encephalitis that was diagnosed on the basis of MR imaging findings and was proved post mortem. In our MR imaging studies, fluid-attenuated inversion recovery images and diffusion-weighted echo-planar images clearly depicted bilateral involvement of the medial temporal ...

Journal: :Cell reports 2016
Etienne Danis Taylor Yamauchi Kristen Echanique Xi Zhang Jessica N Haladyna Simone S Riedel Nan Zhu Huafeng Xie Stuart H Orkin Scott A Armstrong Kathrin M Bernt Tobias Neff

Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional programs. Inactivating alterations of Polycomb repressive complex 2 components are frequent in human ETP-ALL, but their functional role is largely undefined. We have studied the involvement of Ezh2 in a murine model of NRASQ61K-driven le...

2016
Volha Vshyukova Alexander Meleshko Natalia Mihal Olga Aleinikova

•The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL.•IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment.•It's prognostic significance could be more crucial in BCR-ABL- rather than in BCR-ABL + ALL.•IKZF1 gene alterations may be determined and proved at the genome, expression and protein level.•IKZF1 deletions ...

2009
Riccardo Masetti Andrea Pession

Acute lymphoblastic leukemia (ALL) accounts for almost 4000 cases annually in the United States, approximately two thirds of which are in children and adolescents. Treatment results of ALL have improved considerably in the past decade, due to an optimal stratification of patients and a rational use of different antileukemic agents among which L-asparaginase (L-ASNase) plays a fundamental role. ...

Journal: :Haematologica 2013
Petra Dörge Barbara Meissner Martin Zimmermann Anja Möricke André Schrauder Jean-Pierre Bouquin Denis Schewe Jochen Harbott Andrea Teigler-Schlegel Richard Ratei Wolf-Dieter Ludwig Rolf Koehler Claus R Bartram Martin Schrappe Martin Stanulla Gunnar Cario

IKZF1 gene deletions have been associated with a poor outcome in pediatric precursor B-cell acute lymphoblastic leukemia. To assess the prognostic relevance of IKZF1 deletions for patients treated on Berlin-Frankfurt-Münster Study Group trial ALL-BFM 2000, we screened 694 diagnostic acute lymphoblastic leukemia samples by Multiplex Ligation-dependent Probe Amplification. Patients whose leukemic...

2014
Leon Juvenal Hajingabo Sarah Daakour Maud Martin Reinhard Grausenburger Renate Panzer-Grümayer Franck Dequiedt Nicolas Simonis Jean-Claude Twizere

Genomic variations such as point mutations and gene fusions are directly or indirectly associated with human diseases. They are recognized as diagnostic, prognostic markers and therapeutic targets. However, predicting the functional effect of these genetic alterations beyond affected genes and their products is challenging because diseased phenotypes are likely dependent of complex molecular in...

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