The aim of this study was to determine the analgesic effects of pregabalin (a third-generation antiepileptic drug) using the acute thermal pain model (hot-plate test) in mice. Linear regression analysis was used to evaluate a dose-response relationship between logarithms of pregabalin doses and their resultant maximum possible antinociceptive effects (MPAE) using the hot-plate test in mice. Fro...

Pregabalin is an α2-δ ligand indicated for the treatment of peripheral and central neuropathic pain. In this article, we will review the pharmacodynamics, pharmacokinetics, randomized clinical trials supporting its efficacy for a wide array of neuropathic painful conditions, and the tolerability of this medication. We will comment the main differences with gabapentin, its parent compound, both ...

BACKGROUND Oxaliplatin use in gastrointestinal malignancies is limited by neurotoxicity. This study aimed to assess the efficacy of pregabalin (LYRICA(R)) in the treatment of oxaliplatin-induced neurotoxicity. PATIENTS AND METHODS A total of 23 gastrointestinal cancer patients with grade 2 and 3 oxaliplatin-induced sensory neuropathy were treated with pregabalin up to a target dose of 150mg o...

how to cite this article: taghdiri mm, bakhshandeh bali mk, karimzadeh p, ashrafi mr, tonekaboni sh, ghofrani m. comparative efficacy of zonisamide and pregabalin as an adjunctive therapy in children with refractory epilepsy. iran j child neurol. 2015 winter;9(1):49-55. abstract objective approximately one third of epileptic children are resistant to anticonvulsant drugs. this study evaluates t...

Abstract Background Although pregabalin abuse is increasing worldwide and may be associated with increased suicidal ideation behavior, few studies were done in Egypt searching for the effect of on suicide. Eighty-three patients meeting DSM-IV criteria substance disorders related to identified from addiction clinic EL Khanka Psychiatric Hospital this observational cross–sectional study. We inten...

[INTRODUCTION] Pregabalin (Lyrica) is used for the treatment of epilepsy and pain (i.e., neuropathic pain and postsurgical pain). Both its anatomical targets and its mechanism of action are poorly understood [1]. fMRI can map and quantify the strength of pain-related neural activations in spinal cord and brain induced by noxious stimuli. By comparing the fMRI activations before and after delive...

Clinical managements of chronic pain in rheumatoid arthritis (RA) and osteoarthritis (OA) require deep understanding of patients. Since medication is mostly set under the guidelines of RA and OA to control of pain, but personal characteristics is not so much paid attention in terms of preferences. In the present study, alcohol preference was analyzed in the patients prescribed pregabalin and tr...