Background In fertility studies, it has been shown that transforming growth factor β (TGFβ) and interlukin 10 (IL-10) play very important roles in implantation, maternal immune tolerance, placentation and fetal development, and the release beginning of release for fetal and postnatal death. The present study aims to determine the effects of the postmating administration of neutralizing antibodi...

conclusions this study revealed that vitamin c could reduce the fibronectin accumulation effects of nicotine on kidney. results ihc results showed that fibronectin reaction significantly increased in proximal convoluted tubules of exp 1 compared with the control offspring; on the other hand, fibronectin reaction decreased in the mice offspring of exp 2. gene expression results showed that fibro...

Auto antibodies found in the mothers of children with autistic disorder (MCAD) when passively transferred to pregnant mice cause behavioral alterations in juvenile and adult offspring. The goal of this study was to identify whether intraperitoneal injection of MCAD-IgG during gestation affected postnatal cell proliferation and survival in P7 offspring. Pooled MCAD-IgG or IgG from mothers of una...

BACKGROUND The timely onset of powerful uterine contractions during parturition occurs through thick and thin filament interactions, similar to other smooth muscle tissues. Calponin is one of the thin filament proteins. Phosphorylation of calponin induced by PKC-epsilon can promote the contraction of vascular smooth muscle. While the mechanism by which calponin regulates the contraction of preg...

The effect of dosage and pretreatment with phénobarbital or 2-diethylaminoethyl-2,2-diphenylvalerate on the binding of labeled cyclophosphamide and/or its metabolites to macromolecular constituents of the embryo and maternal liver in pregnant mice was studied under conditions nearly identical to those of previous studies of cyclophosphamide teratogenicity. Cyclophosphamide and/or its metabolit...

Methomyl is an oxime carbamate pesticide that is widely used in the Philippines. This insecticide is known to be an endocrine disrupting chemical and a potent genotoxic in mammalian cells. However, limited studies were conducted specifically on its direct effects on estrous cycle and its teratogenic effect. This study aimed to (a) assess the effect of methomyl on the body weight and on the estr...

ABSTRACT AIM: Stress can affect negatively mother and fetuses during pregnancy. We aimed to investigate the effects of chronic immobilization stress on placental maturation fetal development.MATERİALS AND METHODS: Balb/c virgin female mice (20-30 g) were mated with male in a 2 1 ratio. Pregnant control group (n=6) left undisturbed, whereas pregnant exposed 45 min for three times/day starting fr...

Several clinical studies have reported increased placental miR-210 expression in women with PE compared to normotensive women, but whether miR-210 plays a role in the etiology of PE is unknown. We reported that activation of TLR3 produces the PE-like symptoms of hypertension, endothelial dysfunction, and proteinuria in mice only when pregnant, but whether TLR3 activation in pregnant mice and hu...