Nonsense-mediated mRNA decay (NMD) represents a phylogenetically widely conserved splicingand translation-dependent mechanism that eliminates transcripts with premature translation stop codons and suppresses the accumulation of C-terminally truncated peptides. Elimination of frameshifted transcripts that result from faulty splicing may be an important function of NMD. To test this hypothesis di...

The p53 pathway is critical for tumor suppression, as the majority of human cancer has a faulty p53. Here, we identified RNPC1, a p53 target and a RNA-binding protein, as a critical regulator of p53 translation. We showed that ectopic expression of RNPC1 inhibited, whereas knockdown of RNPC1 increased, p53 translation under normal and stress conditions. We also showed that RNPC1 prevented cap-b...

Cells adjust to hypoxic stress within the tumor microenvironment by downregulating energy-consuming processes including translation. To delineate mechanisms of cellular adaptation to hypoxia, we performed RNA-Seq of normoxic and hypoxic head and neck cancer cells. These data revealed a significant down regulation of genes known to regulate RNA processing and splicing. Exon-level analyses classi...

The Escherichia coli signal recognition particle (SRP) system plays an important role in membrane protein biogenesis. Previous studies have suggested indirectly that in addition to its role during the targeting of ribosomes translating membrane proteins to translocons, the SRP might also have a quality control role in preventing premature synthesis of membrane proteins in the cytoplasm. This pr...

We investigate the perturbation in the tunneling current caused by nonadiabatic mechanical motion in a mesoscopic tunnel junction. A theory introduced by Caroli et al.1–3 is used to evaluate second order self-energy corrections for this non-equilibrium situation lacking translational invariance. Inelastic signatures of the mechanical degrees of freedom are found in the current-voltage I(V ) cha...

BACKGROUND Symptom scales for aging women have clinically been used for years and the interest in measuring health-related quality of life (HRQoL) has increased in recent years. The Menopause Rating Scale (MRS) is a formally validated scale according to the requirements for quality of life instruments. The aim of this paper is to review the current state of the instrument particularly concernin...

The notion of Translation Quality Assessment has been the object of many studies. TQA as the compre- hensive treatment of translation evaluation, focuses on the relationship between the source text and target text and also emphasizes that translation is a linguistic operation. To accomplish this research, House‟s model of TQA was chosen as the framework for the investigation ...