BACKGROUND Previously, we reported that prenatal exposures to polycyclic aromatic hydrocarbons (PAH) and postnatal environmental tobacco smoke (ETS) in combination were associated with respiratory symptoms at ages 1 and 2 years. Here, we hypothesized that children exposed to both prenatal PAH and ETS may be at greater risk of asthma and seroatopy at ages 5-6 years, after controlling for current...

BACKGROUND The reasons why women do not obtain prenatal care even when it is available and accessible are complex. Despite Canada's universally funded health care system, use of prenatal care varies widely across neighborhoods in Winnipeg, Manitoba, with the highest rates of inadequate prenatal care found in eight inner-city neighborhoods. The purpose of this study was to identify barriers, mot...

OBJECTIVE To evaluate coverage by the Prenatal and Birth Humanization Program, according to its minimal requirements and process indicators, by comparing information from prenatal booklets to SISPRENATAL (System to Accompany the Prenatal and Birth Humanization Program). METHODS A cross-sectional study was carried out with prenatal data from 1,489 women in the postpartum period after birth in ...

BACKGROUND The objectives of this study were to determine rates of prenatal care utilization in Winnipeg, Manitoba, Canada from 1991 to 2000; to compare two indices of prenatal care utilization in identifying the proportion of the population receiving inadequate prenatal care; to determine the association between inadequate prenatal care and adverse pregnancy outcomes (preterm birth, low birth ...

OBJECTIVE To analyze the association between physical violence by an intimate partner (PVIP) and the inappropriate use of prenatal care services. METHODS A nested cross-sectional study was conducted with 1,026 women, based on data from a prospective cohort study designed to investigate intimate partner violence among pregnant women enrolled in the Family Health Program (PSF) in Recife, Northe...

congenital granular cell tumor (gct) is a relatively rare intraoral benign tumor, approximately 200 cases of which have been reported in the neonatal period worldwide. the newborn infant may have feeding problems and respiratory difficulties due to airway obstruction. this lesion may be diagnosed by prenatal ultrasonography and simple resection is mostly required. we report a case of an adult t...

OBJECTIVE The study explores the prenatal Child Abuse Potential (pCAP) scores derived from the Child Abuse Potential Inventory administered to expectant adolescent mothers. The aim of the study was to assess the association of the pCAP scores with maternal negative prenatal behaviors, and evaluate the contribution of the pCAP scores to neonatal morbidity. METHOD The pCAP scores, demographic d...

To study cocaine's toxic effects in vitro, we have used primary mesencephalic and striatal cultures from rat embryonic brain. Treatment with cocaine causes a dramatic increase in DNA fragmentation in both primary cultures. The toxicity induced by cocaine was paralleled with a concomitant decrease in the microtubule associated protein 2 (MAP2) and/or neuronal nucleus protein (NeuN) staining. We ...

We construct optimal designs for estimating fetal malformation rate, prenatal death rate and an overall toxicity index in a toxicology study under a broad range of model assumptions. We use Weibull distributions to model these rates and assume that the number of implants depend on the dose level. We study properties of the optimal designs when the intra-litter correlation coefficient depends on...