نتایج جستجو برای: prenylation
تعداد نتایج: 805 فیلتر نتایج به سال:
C iliary dysfunction underlies multiple human genetic diseases, and mechanisms of protein trafficking to cilia are an area of active investigation. PDE6D (also known as PDEd and PrBP) is a prenylbinding protein involved in ciliary targeting of prenylated proteins [1–4]. Previous studies uncovered that PDE6D interacts with RPGR [5,6], mutations of which cause retinitis pigmentosa [7–10]. More re...
In Saccharomyces cerevisiae, Chs4p is required for chitin synthase III (CSIII) activity and hence for chitin synthesis. This protein is transported in vesicles in a polarized fashion independently of the other Chs proteins. Its association with membranes depends not only on prenylation, but also on its interaction with other proteins, mainly Chs3p, which is the catalytic subunit of CSIII and is...
Primary cilia are microtubule-based organelles, which protrude from the plasma membrane and receive a wide range of extracellular signals. Various cilia use G protein-coupled receptors (GPCRs) for the detection of these signals. For instance, vertebrate rod photoreceptors use their cilia (also called outer segments) as antennae detecting photons by GPCR rhodopsin. Rhodopsin recognizes incoming ...
The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and farnesylpyrophosphate (FPP) used in the prenylation of proteins. Here we show that the MEV cascade inhibitor simvastatin induced significant cell death in a wide range of human tumor cell lines, including glioblastoma, astrocytoma, neu...
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