Homoallylic ketones combine arguably two of the most synthetically useful functional groups in organic chemistry and are, therefore, very valuable synthetic intermediates. General methods for the synthesis of these intermediates include the allylation of carbonyl compounds via p-allyl palladium(II) complexes, the 1,4-addition of vinylmetal nucleophiles onto a,bunsaturated compounds, and the Cla...

Thiosemicarbazides are potent intermediates for the synthesis of pharmaceutical and bioactive materials and thus, they are used extensively in the field of medicinal chemistry. The imine bond (-N=CH-) in these compounds are useful in organic synthesis, in particular for the preparation of heterocycles and non-natural β-aminoacids.In this paper the synthesis of some new thiosemicarbazide derivat...

The first synthesis of a series of ketones naturally occurring in E. pallida is described. The natural distribution of these ketones among different Echinacea species is also reported.

This review paper covers the major synthetic approaches attempted towards the synthesis of α-azido ketones, as well as the synthetic applications/consecutive reactions of α-azido ketones.

We tested the Binding Threshold Hypothesis (BTH) for activation of olfactory receptors (ORs): To activate an OR, the odorant must bind to the OR with binding energy above some threshold value. The olfactory receptor (OR) 912-93 is known experimentally to be activated by ketones in mouse, but is inactive to ketones in human, despite an amino acid sequence identity of approximately 66%. To invest...

Chiral chelated lithium amides were designed and synthesized. Studies have been done to explore the use of these lithium amides or their corresponding amines for enantioselective reactions such as deprotonation of prochiral cyclic ketones, kinetic resolution of racemic 2-substituted cyclohexanones by deprotonation, regioselective deprotonation of optically active 3-keto steroids, alkylation of ...

Indium(III) triflate is found to be an effective catalyst for the benzannulation reactions of o-alkynylbenzaldehydes with enolisable aldehydes, ketones, 1,3-diketones and β-keto esters. The reactions produce naphthyl ketones through ring opening of adducts arising from the inverse electron demand Diels-Alder reactions between in situ generated isochromenylium cations and enols. The main feature...

Biocatalytic procedures can circumvent some of the drawbacks that classical methodologies present in chemical synthesis. One example is shown by the Baeyer-Villiger (BV) reaction, a process discovered more than 100 years ago that consists in the nucleophilic insertion of one atom of oxygen in the adjacent position of a carbonyl moiety affording esters or lactones. This reaction proceeds using p...