Phenytoin (PHT) oxidative route leads to its main metabolite p-hydroxyphenytoin (p-HPPH), by means of CYP2C9 and CYP2C19. Formation of p-HPPH proceeds via a reactive arene-oxide intermediate. This intermediate can also be converted into PHT dihydrodiol by microsomal epoxide hydrolase (EPHX). The three enzymes are polymorphically expressed and the genetic variants are responsible for changes in ...

We have developed an experimental platform that allows a large number of human participants to interact in real-time within a common virtual world. Within this environment, human participants foraged for resources distributed in two pools. In addition to varying the relative replenishment rates for the two resources (50-50, 65-35, 80-20), we manipulated whether participants could see each other...

The production of tubular fluid (TF) and interstitial fluid (IF) in normal and irradiated testes was compared in the same growing rats submitted at 25 days of age to unilateral, scrotal X-ray, exposure. Twelve rats were sacrificed each week from 32 to 81 days of age. In both normal and irradiated testes, IF increased in parallel with the testicular weight until 67 days of age and declined sligh...

The Internet Protocol (IP) environment poses two relevant sources of distortion to the speech recognition problem: lossy speech coding and packet loss. In this paper, we propose a new front-end for speech recognition over IP networks. Specifically, we suggest extracting the recognition feature vectors directly from the encoded speech (i.e., the bit stream) instead of decoding it and subsequentl...

Only little systematic research has examined event-related brain potentials (ERPs) elicited by the cognitive processing of music. The present study investigated how music processing is influenced by a preceding musical context, affected by the task relevance of unexpected chords, and influenced by the degree and the probability of violation. Four experiments were conducted in which "nonmusician...

OBJECTIVE To assess the relative frequency of the different causes of pompholyx evoked in the literature. DESIGN Prospective survey. SETTING Clinical outpatient setting. PATIENTS A total of 120 consecutive patients with pompholyx referred to our department from 2000 through 2003. MAIN OUTCOME MEASURES Systematic investigation of different causes of pompholyx: fungal intertrigo, hyperhid...

BACKGROUND The persistent high prevalence of human scabies, especially in low- and middle-income countries prompted us to research the sociodemographic profile of patients suffering from it, and its spreading factors in Cameroon, a resource-poor setting. METHODS We conducted a cross-sectional survey from October 2011 to September 2012 in three hospitals located in Yaoundé, Cameroon, and enrol...

UNLABELLED Idiopathic scoliosis is a three-dimensional deformation of the spine. As its name suggests, its pathogenesis remains poorly understood. Enhanced comprehension of its pathogenesis would be likely to improve current therapeutic results. While the hereditary and genetic origin of scoliosis appears unassailable and several chromosomes are known to be involved in transmission, the role as...

Sustainable consumption has positioned itself as an alternative for economic growth and social development because of its ability to deal with the future scarcity natural resources prevention mitigation climate change, among other things. In this sense, role consumer is preponderant, due fact their behaviour a direct effect on environment; hence importance analysing habits from different perspe...

Progressive neurodegenerative pathologies in aged populations are an issue of major concern worldwide. The microtubule-associated protein tau is able to self-aggregate to form abnormal supramolecular structures that include small oligomers up to complex polymers. Tauopathies correspond to a group of diseases that share tau pathology as a common etiological agent. Since microglial cells play a p...