Systemic amyloidoses are a wide group of diseases with different courses, treatments and prognoses. Unequivocal typing of amyloid deposits is important for correct diagnosis and appropriate treatment. At present, the most effective therapeutic approach is based on eliminating the supply of amyloidogenic precursor. New effective therapies will stem from our improved knowledge of the molecular me...

Primary systemic amyloidosis is a rare disorder that has multisystemic manifestations. The diagnosis is very diffi cult because of non-specifi c clinical signs. We report a patient with primary systemic amyloidosis manifesting as peripheral neuropathy, nephrotic syndrome, gastrointestinal syndrome, orthostatic hypotension, pericardial fl uid, weight loss and so on. Histopathological examination...

Objective The complication of systemic immunoglobulin light chain (AL) amyloidosis in patients with monoclonal immunoglobulin affects the prognosis, but amyloid deposition in tissues is sometimes difficult to detect due to bleeding tendencies and preferential distributions. However, fibrinolysis is known to be exacerbated in patients with systemic AL amyloidosis specifically. We therefore explo...

Aims In transthyretin amyloid (ATTR) amyloidosis various principal phenotypes have been described: cardiac, neuropathic, or a mixed cardiac and neuropathic. In addition, two different types of amyloid fibrils have been identified (type A and type B). Type B fibrils have thus far only been found in predominantly early-onset V30M and in patients carrying the Y114C mutation, whereas type A is note...

A 39 year old Caucasian male presented with a 10 day history of visible painless haematuria. He had one previous episode of haematuria ten months prior to this following ozone therapy for Lyme's disease. His past medical history included alopecia and chronic fatigue syndrome. He took no regular medications. There were no risk factors for transitional cell carcinoma (TCC) of the bladder. An ultr...

Primary laryngeal amyloidosis is a rare benign disease of unknown aetiology. It can present with dysphonia or stridor. A woman presenting with airway compromise, who required a tracheostomy, is reported.

Nodular cutaneous amyloidosis (NCA), the least common form of primary cutaneous amyloidosis, is characterized clinically by waxy, purpuric plaques and nodules and histologically by amyloid deposits in the dermis and subcutaneous tissue. We present a patient who developed multiple, non-contiguous NCA lesions over a three year period without evidence of systemic disease. We reviewed the literatur...

To cite: Al-Adhami A, Steiner K, Ellis S. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016216548 DESCRIPTION We present an unusual case of primary systemic amyloidosis presenting with myopathy and peritoneal amyloid deposition. Peritoneal amyloid is a rare disease with few published cases. An 85-year-old man was referred to rheumatology with walking difficulti...

To the Editor: Apolipoprotein AI (AApoAI)–associated amyloidosis is characterized by the deposition of apolipoprotein AI (apoAI) and occurs as a hereditary and a nonhereditary form. Hereditary AApoAI amyloidosis is a systemic disease leading to the deposition of amyloid in various organs and tissues and is caused by germline mutations in the APOA1 gene. Nonhereditary AApoAI amyloid is far more ...