Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signaling is involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the most common subtypes of cutaneous T-cell lymphoma. By immunohistochemistry of 40 biopsies taken from skin lesions of mycosis fungoides and Sézary syndrome, w...

T-cell/histiocyte-rich diffuse large B-cell lymphoma is characterized by abundant reactive T-cell and histiocyte infiltration within nodal diffuse large B-cell lymphoma, and only limited cases of primary cutaneous T-cell-rich B-cell lymphoma have been documented. These reactive T-cells usually show a T-helper phenotype. Gamma/delta T-cell is a functionally distinct T-cell lineage, which constit...

background : cutaneous metastasis is defined as the spread of malignant cells from a primary malignancy to the skin. generally, cutaneous involvement from internal malignancies is uncommon. no reports have focused on the cutaneous metastasis profiles in egypt or the middle eastern population. in this study, we seek to determine the rates at which different internal malignancies give rise to cut...

AIM To study the immunohistochemical expression of the Thomsen-Friedenreich antigen (T) and its precursor, Tn, in the skin in various cancers. METHODS T and Tn antigens were studied with monoclonal antibodies in 91 primary premalignant and malignant lesions, 13 cases of Paget's disease, and 26 carcinomas metastatic to the skin. The material had been collected over a 10 year period, formalin f...

Aim: The aim of this article is to characterize in detail the γδ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma subtype (γδ CTCL). Methods: Here reports trajectory mapping on high-resolution differentiation trajectories digitally extracted a scRNAseq dataset. Results: In patch-to-plaque progression CTCL, TCRVγnon9 subset cells differentiated naive (Tn) and central me...