Primary hyperaldosteronism, one cause of which is aldosterone-producing adenomas (APAs), may account for 5% to 10% of cases of essential hypertension. Germline mutations have been identified in 2 rare familial forms of primary hyperaldosteronism, but it has been reported recently that somatic mutations of the KCNJ5 gene, which encodes a potassium channel, are present in some sporadic nonsyndrom...

UNLABELLED We describe a young male patient with longstanding hypertension, who was diagnosed with primary hyperaldosteronism and treated by an attempted retroperitoneoscopic total unilateral adrenalectomy for a left-sided presumed aldosterone-secreting adenoma. Imaging had shown an unremarkable focal adrenal lesion with normal contralateral adrenal morphology, and histology of the resected spe...

Cirrhotic ascites, in which secondary hyperaldosteronism is a notable feature, is associated with impaired gastric secretion (Baddeley, 1968). Obstruction to hepatic venous outflow, which also induces secondary hyperaldosteronism and ascites (Orloff, Ross, Baddeley, Nutting, Spitz, Sloop, Neesby, and Halasz, 1964), depresses acid secretion from Heidenhain pouches in dogs with cirrhotic and non-...

The common practice of encouraging forearm exercise as an aid to venepuncture is a potent source of erroneously high plasma potassium levels. This may be sufficient to obscure a suspicion of hyperaldosteronism, with possible serious repercussions in hypertensive patients, in whom the diagnosis of hyperaldosteronism has important therapeutic implications. Plasma is preferable to serum for potass...

Cirrhotic ascites, in which secondary hyperaldosteronism is a notable feature, is associated with impaired gastric secretion (Baddeley, 1968). Obstruction to hepatic venous outflow, which also induces secondary hyperaldosteronism and ascites (Orloff, Ross, Baddeley, Nutting, Spitz, Sloop, Neesby, and Halasz, 1964), depresses acid secretion from Heidenhain pouches in dogs with cirrhotic and non-...

Primary hyperaldosteronism typically leads to resistant hypertension, hypokalemia, and metabolic alkalosis. Excess aldosterone secretion by the adrenal glands may lead heart failure with preserved ejection fraction. Potassium-sparing diuretics antagonists directed lower excess levels help treat associated control of blood pressure, resulting in improved outcomes. We report a case 55-year-old ma...

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a very heterogeneous entity. The incidental identification of an increasing number cases has shifted its clinical expression. Both in terms cortisol excess and with mild forms asymptomatic oligosymptomatic less impressive imaging phenotypes. Activation the cAMP/PKA pathway, either due to alteration various downstream signaling pathwa...