The priming principle was investigated in the rat phrenic nerve-diaphragm preparation stimulated continuously at 0.2 Hz. Tubocurarine was added to the organ bath as either a single (non-primed) or a divided (primed) dose. Priming consisted of 15% or 20% of the final dose, with priming intervals of 5 or 10 min. Priming decreased significantly the time to 80% block and was associated with mild ne...

Speakers produce words to convey meaning, but does meaning alone determine which words they say? We report three experiments that show independent semantic and phonological influences converging to determine word selection. Speakers named pictures (e.g., of a priest) following visually presented cloze sentences that primed either semantic competitors of the target object name ("The woman went t...

This paper examines a novel means of increasing elaboration of persuasive messages. Whereas much previous research has focused on ways to promote actual self-relevance of the message (e.g., by changing the message to match the recipient), the present research uses priming manipulations to change the recipient to match the message. Across two studies, participants were primed with traits (e.g., ...

Highly optimistic explanatory style (HOES) and highly pessimistic explanatory style (HPES) are two maladaptive ways to explain the world and may have roots in attachment insecurity. The current study aims to explore the effects of security priming - activating supportive representations of attachment security - on ameliorating these maladaptive explanatory styles. 57 participants with HOES and ...

DNA replication in Archaea, as in other organisms, involves large protein complexes called replisomes. In the Euryarchaeota subdomain, only two putative replicases have been identified, and their roles in leading and lagging strand DNA synthesis are still poorly understood. In this study, we focused on the coupling of proliferating cell nuclear antigen (PCNA)-loading mechanisms with DNA polymer...

We have examined the abilities of helper T cells from commercially available (CBA/N X BALB/c)F1 (NBF1) xid male and phenotypically normal female mice to help T15+ and T15- B cells to produce thymus-dependent phosphorylcholine (PC)-specific direct plaque-forming cell responses. Carrier-primed T cells from both male and female mice were found (a) to restore T15+ TD responses in congenitally athym...

Abstract Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we capture characterize in vitro primed quiescent identify LRIG1 an important regulator. We show that BMP-4 signaling induces dormant non-cycling state (d-qNSCs), whereas combined BMP-4/FGF-2 distinct poised for c...

Arachidonic acid (AA) generated by phospholipase A(2) (PLA(2)) is thought to be an essential cofactor for phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. Both enzymes are simultaneously primed by cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF-alpha). The possibility that either unprimed or cytokine...

Mesenchymal stem cells (MSCs) are known to both have powerful immunosuppressive properties and promote allograft tolerance. Determining the environmental oxygen tension and inflammatory conditions under which MSCs are optimally primed for this immunosuppressive function is essential to their utilization in promoting graft tolerance. Of particular interest is the mechanisms governing the interac...

The authors propose that automatic social behavior may result from perceivers preparing to interact with primed social group members. In Study 1, participants primed with a disliked outgroup (gay men) showed evidence of interaction preparation (aggression) rather than direct stereotypic trait expression (passivity). In Study 2, participants with implicit positive attitudes toward the elderly wa...