Pulse radiolysis was applied to study the reactivity of *OH radicals with procarbazine (PC), a cytostatic agent widely used in radiation- and chemotherapy. An overall rate constant of k(*OH+PC) = 3.7 x 10(9) l.mol(-1).s(-1) was determined. The thereby formed transients had a strong absorption at 350 nm, epsilon350 = 4.46 x 10(3) l.mol(-1).cm(-1), and a weak absorption band around 530 nm. Comput...

PURPOSE Procarbazine hydrochloride (PCB) is one of the few anticancer drugs with activity against high-grade gliomas. This study was conducted to determine if the maximum tolerated dose and pharmacokinetics of PCB are affected by the concurrent use of enzyme-inducing antiseizure drugs (EIASD). EXPERIMENTAL DESIGN Adults with recurrent high-grade glioma were divided into cohorts who were (+) a...

Procarbazine (PCZ) (indicated in Hodgkin's disease), is an alkylating agent known to generate free radicals in vivo, while Quercetin (QCT) is a flavonoid antioxidant with proven free radical scavenging capacity. This study investigated the protective effects of QCT on PCZ-induced oxidative damage in the rat. Male Wistar rats (160-180 g) were randomized into five groups (n = 5/group): I (control...

PURPOSE Temozolomide (TMZ) is an alkylating agent licensed for treatment of high-grade glioma (HGG). No prospective comparison with nitrosourea-based chemotherapy exists. We report, to our knowledge, the first randomized trial of procarbazine, lomustine, and vincristine (PCV) versus TMZ in chemotherapy-naive patients with recurrent HGG. PATIENTS AND METHODS Four hundred forty-seven patients w...

K Van Den Bogaert, E M R De Leenheer, W Chen, Y Lee, P Nürnberg, R J E Pennings, K Vanderstraeten, M Thys, C W R J Cremers, R J H Smith, G Van Camp . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

(a) If we consider the intersections of the circle Hi(O) (center Hi and radius HiO) with the line Ai+1Ai+2, then we obtain six points which all lie on a circle with center H (first Droz-Farny circle). (b) If we consider the intersections of the circle Mi(H) (center Mi and radius MiH) with the line AiAi+1, then we obtain six points which all lie on a circle with center O (second Droz-Farny circl...

The meteorological and sanitary conditions which favor the outbreak and progress of cholera have in many ways a similar influence in fostering and spreading flies. The peculiarities with regard to localisation and movement which have been recorded in some epidemics of cholera are, to my mind, explicable only by assuming the presence in the air of some animal capable of purposive movements and c...