BACKGROUND It is recommended to optimise treatment as long as a predefined treatment target is not met, but should the aim be remission if patients are in low disease activity (LDA)? The aim of this study was to assess if, in patients with rheumatoid arthritis (RA) or patients with undifferentiated arthritis (UA) with Disease Activity Score (DAS) ≤ 2.4 (LDA), treatment intensification results i...

The continuous innovation in hydrogenation technology is testimony to its growing importance in the manufacture of specialty and fine chemicals. New developments in equipment, process intensification and catalysis represent major themes that have undergone recent advances. Developments in chiral catalysis, methods to support and fix homogeneous catalysts, novel reactor and mixing technology, hi...

OBJECTIVES To investigate the optimal systolic blood pressure goal above which new antihypertensive medications should be added or doses of existing medications increased ("systolic intensification threshold") and to determine the relation between delays in medication intensification and follow-up and the risk of cardiovascular events or death. DESIGN Retrospective cohort study. SETTING Pri...

OBJECTIVE To compare information obtained from narrative and structured electronic sources using anti-hypertensive medication intensification as an example clinical issue of interest. DESIGN A retrospective cohort study of 5,634 hypertensive patients with diabetes from 2000 to 2005. MEASUREMENTS The authors determined the fraction of medication intensification events documented in both narrativ...

We are in danger of losing our current standards living due to the depletion natural resources. It is essential decrease amount waste produced. In reactor engineering, production caused by formation byproducts. To increase selectivity reactor, fluid dynamics should benefit intrinsic reaction kinetics, which can only be done when each molecule has exactly same experience. The mass transfer from ...

Land-use and land-cover change research needs to pay more attention to processes of land-cover modification, and especially to agricultural land intensification. The objective of this paper is to review the different modelling approaches that have been used in land-use/land-cover change research from the perspective of their utility for the study and prediction of changes in land-use intensific...

Biodiesel is a promising fuel alternative compared to traditional diesel obtained from conventional sources such as fossil fuel. Many flowsheet alternatives exist for the production of biodiesel and therefore it is necessary to evaluate these alternatives using defined criteria and also from process intensification opportunities. This work focuses on three main aspects that have been incorporat...