The multi-product dynamic lot sizing problem with product returns and recovery is an important problem that appears in reverse logistics and is known to be NP-hard. In this paper we propose an efficient variable neighborhood descent heuristic algorithm for solving this problem. Furthermore, we present a new benchmark set with the largest instances in the literature. The computational results, d...

We generalize the construction of locally recoverable codes on algebraic curves given by Barg, Tamo and Vlăduţ [4] to those with arbitrarily many recovery sets by exploiting the structure of fiber products of curves. Employing maximal curves, we create several new families of locally recoverable codes with multiple recovery sets, including codes with two recovery sets from the generalized Giuli...

An approximate error function for the discretization error on a given mesh is obtained by projecting (via the energy inner product) the functional residual onto the space of continuous, piecewise quadratic functions which vanish on the vertices of the mesh. Conditions are given under which one can expect this hierarchical basis error estimator to give efficient and reliable function recovery, a...

In this paper, we study various parallelization schemes for the Variable Neighborhood Search (VNS) metaheuristic on a CPU-GPU system via OpenMP and OpenACC. A hybrid parallel VNS method is applied to recent benchmark problem instances for the multi-product dynamic lot sizing problem with product returns and recovery, which appears in reverse logistics and is known to be NP-hard. We report our f...

Freeze dried cryoprecipitate was used in the treatment of 14 patients with haemophilia A. The in vivo recovery was 91.2% which is comparable to that reported from other parts of Europe. The product was efficacious and no adverse effects were reported. Freeze dried cryoprecipitate is the high yield product of a low technology process and as such may be of value in reducing any possible shortfall...

In this paper, we address the problem of locating collection centers for a company that collects used products from product holders. Each product holder has an inherent willingness to return the product, and makes the decision on the basis of financial incentive offered by the company. We present a mixed-integer nonlinear facility location-allocation model to find the optimal locations, the opt...

This paper describes experiences with the architectural specification and tool-assisted architectural analysis of a mission-critical, high-performance software product line. The approach used defines a ‘‘good’’ product line architecture in terms of those quality attributes required by the particular product line under development. Architectures are analyzed against several criteria by both manu...

Software product lines often arise from a set of variants of a common code basis that have been individually adapted to a particular requirement variability. This ad-hoc and unplanned approach causes serious maintenance problems. Migrating such variants into an organized software product line promises better maintainability. In this talk, I shall outline our 3-year research program aiming at co...

The immune system plays a critical role determining the outcomes in transplanted multiple myeloma patients, since enhanced lymphocyte recovery results in improved survival. Since mobilization regimens influence the cellular subsets collected and infused for transplant, these regimens may determine immune recovery following transplant. We hypothesized that a mobilized stem cell product harboring...

Given the large amount of crude glycerol formed as a by-product in the biodiesel industries and the concomitant decrease in its overall market price, there is a need to add extra value to this biorefinery side stream. Upgrading can be achieved by new biotechnologies dealing with recovery and conversion of glycerol present in wastewaters into value-added products, aiming at a zero-waste policy a...