In models of hind-limb ischemia and progressive coronary artery occlusion, angiogenic growth factor proteins and genes expressing growth factors have been shown to induce the development of collateral vessels and remodeling of existing collaterals. The therapeutic potential of growth factors in the setting of acute myocardial infarction may be related to non-angiogenic properties of growth fact...

Chronic, progressive, and irreversible loss of a transplanted kidney function, previously named chronic allograft nephropathy, is the leading cause of chronic allograft failure among kidney transplant recipients. Chronic allograft dysfunction (CAD) is a multifactorial process associated with progressive interstitial fibrosis and tubular atrophy. Current Data confirms that an additive series of ...

resorption of tooth structures can occur as a result of physiological, pathological, and idiopathic factors. early diagnosis and appropriate treatment can prevent its serious complications. this case report presents surgical endodontic management of a trauma-induced perforating external root resorption, which was diagnosed with the help of cone beam computed tomography. following root canal tre...

progressive collapse is defined as the spread of an initial failure from element to element, eventually resulting in the collapse of an entire structure or a disproportionately large part of it. the current progressive collapse analyses and design methods in guidelines and codes focus on the alternate load path method. this method is suitable especially in the case of blast-induced progressive ...

4 Gastroenterology & Hepatology Volume 6, issue 12, supplement 17 December 2010 icant adverse effects, including progressive multifocal leukoencephalopathy, a rare but severe neurologic complication, which has caused the US Food and Drug Administration to place stipulations on the use of this drug. Recent Advances in Treatment: The 2010 ACG Meeting Recent and ongoing studies have continued to e...

Several aspects of the management of Crohn's disease (CD) are shared between patients. The goal of all therapies should be to achieve clinical and endoscopic remission in a timely manner to avoid disease progression and abdominal resections. The way this goal is achieved may differ and predicting how the disease will evolve, what the most appropriate therapy with the highest chance of success w...

Tumour necrosis factor (TNF)-α, a proinflammatory cytokine central to many autoimmune diseases, has been implicated in the depigmentation process in vitiligo. We review its role in vitiligo by exploring its pro- and anti-inflammatory properties and examine the effects of blocking its actions with TNF-α antagonist therapeutics in reports available in the literature. We found that TNF-α inhibitio...

An important issue in critiquing approaches to product recommendation is how to avoid long and fruitless critiquing dialogues when none of the available products are acceptable to the user. We present a new approach called progressive critiquing in which the non-existence of a product that satisfies all the user's critiques triggers an explanation alerting the user to the possibility that none ...

The severity and the duration of acute human immunodeficiency virus (HIV) infection (AHI) are associated with a faster rate of progression to AIDS, but the prognostic value of the length of incubation time of AHI (IncAHI), defined as the time between HIV infection and AHI, on progression to AIDS has not been assessed. We explored this issue prospectively in 70 individuals with documented AHI an...