Proliferative nodules can occasionally arise on congenital and acquired melanocytic nevi. At first sight their clinical and pathologic features cause alert to both dermatologist and dermatopathologist. However, proliferative nodules are typically benign, regression is common and there is minimum risk of malignization. We present a new case of proliferative nodule in melanocytic nevi with featur...

Proliferative pulmonary vascular remodeling is the pathologic hallmark of pulmonary arterial hypertension (PAH) that ultimately leads to right heart failure and death. Highly proliferative endothelial cells known as endothelial colony-forming cells (ECFC) participate in vascular homeostasis in health as well as in pathological angiogenic remodeling in disease. ECFC are distinguished by the capa...

BACKGROUND Basal cell carcinoma (BCC) is the most common malignancy in humans. Several factors have been associated with the biological behavior of these tumors, including histopathologic type, depth of tumor invasion, perineural invasion, and the expression of several biological markers including Ki67, a proliferative marker. Previous studies assessing the relationship between the proliferativ...

Diabetic Retinopathy (DR) is a complication of diabetes associated with irreversible loss of blindness. Various types of DR have been reported like mild non-proliferative retinopathy, moderate non-proliferative retinopathy, severe non-proliferative retinopathy and proliferative retinopathy. A number of signaling mechanisms like nuclear factor kappa-B (NF-κB), cyclo-oxygenase (COX), intracellula...

The proliferative activity of 16 tumour specimens from 13 patients with neuroendocrine tumours of the gastroenteropancreatic endocrine system was studied by DNA flow cytometry and immunohistology for the nuclear Ki67 proliferation antigen. Equivalent results were obtained with both methods, which showed the proliferative activity of gastroenteropancreatic neuroendocrine tumours to be heterogene...

Invasive and proliferative phenotypes are fundamental components of malignant disease, yet basic questions persist about whether tumor cells can express both phenotypes simultaneously and, if so, what are their properties. Suitable in vitro models that allow characterization of cells that are purely invasive are limited because proliferation is required for cell maintenance. Here, we describe g...

Proliferative myositis is a rare pseudosarcomatous inflammatory process. Radiological diagnosis of self-limiting proliferative myositis helps direct appropriate clinical management and avoiding unnecessary surgical excision. We present the ultrasonography, computed tomography, and magnetic resonance imaging findings in a case of proliferative myositis. In this case, malignancy was suspected, an...