BACKGROUND Prophylactic cranial irradiation reduces the incidence of brain metastasis in patients with small-cell lung cancer. Whether this treatment, when given to patients in complete remission, improves survival is not known. We performed a meta-analysis to determine whether prophylactic cranial irradiation prolongs survival. METHODS We analyzed individual data on 987 patients with small-c...

objective: pain control in dentistry especially endodontics is particularly important. endodontic pain following root canal therapy (rct) of vital teeth is closely correlated with inflammatory reactions. increased level of prostaglandins has been reported in acute inflammatory reactions. thus, cyclooxygenase-inhibiting drugs have a significant effect on reducing pain and inflammation. cox enzym...

OBJECTIVE In patients with spontaneous intracerebral hemorrhage (ICH), the risk factors for seizure and the effect of prophylactic anticonvulsants are not well known. This study aimed to determine the risk factor for seizures and the role for prophylactic anticonvulsants after spontaneous ICH. METHODS Between 2005 and 2010, 263 consecutive patients with spontaneous ICH were retrospectively as...

OBJECTIVE To determine the evidence-based value of prophylactic drainage in gastrointestinal (GI) surgery. METHODS An electronic search of the Medline database from 1966 to 2004 was performed to identify articles comparing prophylactic drainage with no drainage in GI surgery. The studies were reviewed and classified according to their quality of evidence using the grading system proposed by t...

BACKGROUND/AIMS This meta-analysis was undertaken to evaluate the effect of rectal indomethacin in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. MATERIALS AND METHODS Major databases including Embase, Medline, Science Citation Index Expanded, Pubmed and the Cochrane Central Register of Controlled Trials, were searched to identify all relevant studi...

This study was performed to investigate the effects of adrenocorticoid steroids, Prednisolone sodium hemisuccinate, Dexamethasone, and Betamethasone disodium phosphate, on the wound healing of permanent pacemaker implantation, especially on the :findings of redness and local hemorrhage. It was found that prednisolone sodium hemisuccinate and betamethasone disodium phosphate had a remarkable pro...

PURPOSE A systematic review was performed to find evidence for prophylactic administration of antibiotics in relation to treatment of maxillofacial fractures. METHODS Four studies were retrieved that fulfilled most of the requirements of being randomized controlled clinical trials. RESULTS An analysis of these studies showed a 3-fold decrease in the infection rate of mandibular fractures in...

conclusions in conclusion, the extract of feverfew showed a significant migraine prophylactic effect with no adverse events. results in the case group, after three months of treatment with feverfew, the midas score was reduced to 19.18 ± 4.02. compared to control group, the changes in intensity and frequency of migraine, in the treatment group was significant, at the end of the study (p < 0.05)...