MOTIVATION The flow of information within cellular pathways largely relies on specific protein-protein interactions. Discovering such interactions that are mostly mediated by peptide recognition modules (PRM) is therefore a fundamental step towards unravelling the complexity of varying pathways. Since peptides can be recognized by more than one PRM and high-throughput experiments are both time ...

Feasibility and efficacy of transcutaneous spinal cord stimulation (tSCS) have been studied during the last years. A key parameter to study this technique is posterior root muscle response (PRM), which a monosynaptic reflex that evoked by single pulse tSCS. The objective work was analyse how body weight loading influences PRM threshold in subjects with injury (SCI).

BACKGROUND Piezoresistive pressure measurement technique (PRM) has previously been applied for direct IAP measurement in a porcine model using two different devices. Aim of this clinical study was to assess both devices regarding complications, reliability and agreement with IVP in patients undergoing elective abdominal surgery. METHODS A prospective cohort study was performed in 20 patients ...

It has been known that the performance of high-pressure grinding rolls (HPGR) varies as a function method used to laterally confine rolls, their diameter/length (aspect) ratio well condition, if new or worn. However, quantifying these effects through direct experimentation in machines with reasonably large dimensions is not straightforward, given challenge, among others, guaranteeing feed mater...

We introduce a hierarchical variant of the probabilistic roadmap method for motion planning. By recursively refining an initially sparse sampling in neighborhoods of the C-obstacle boundary, our algorithm generates a smaller roadmap that is more likely to find narrow passages than uniform sampling. We analyze the failure probability and computation time, relating them to path length, path clear...

Compared with other flaviviruses, Zika virus (ZIKV) is uniquely associated with congenital diseases in pregnant women. One recent study reported that (i) ZIKV has higher thermostability than dengue virus (DENV [a flavivirus closely related to ZIKV]), which might contribute to the disease outcome; (ii) the higher thermostability of ZIKV could arise from an extended loop structure in domain III o...

the management of machine replacement (specifically tractors) is one of the most critical factors for performing field operations on time. therefore, tractor repair and maintenance costs must be accurately predicted. this research was carried out to evaluate the use of the regression technique in predicting tractor repair and maintenance costs. the study was conducted using empirical data on 60...

In this paper, we use a novel duration model to study joint retirement in married couples using the Health and Retirement Study. Whereas conventionally used models cannot account for joint retirement, our model admits joint retirement with positive probability and nests the traditional proportional hazards model. In contrast to other statistical models for simultaneous durations, it is based on...