نتایج جستجو برای: protein stability
تعداد نتایج: 1503740 فیلتر نتایج به سال:
p53 tumor suppressor gene, also known as “genome guardian” is mutated in more than half of allkind of cancers. in this study we have investigated the controls of environmental ph for p53 genemutation in point of specific sequence which is prone to mutagenesis. the most probable cancerousmutations occur as point mutations in exons 5-8 of p53 gene. the 175th codon of p53 is the thirdmost mutated ...
In this paper numerical results are reviewed ([13]) that demonstrate that common second-order operator-splitting methods can exhibit instabilities when integrating the Brusselator equations out to moderate times of about seven periods of oscillation. These instabilities are manifested as high wave number spatial errors. In this paper we further analyze this problem and present a theorem for sta...
This study shows significant effects of protein surface charges on stability and these effects are not eliminated by salt screening. The stability for a variant of protein G B1 domain was studied in the pH-range of 1.5-11 at low, 0.15 M, and 2 M salt. The variant has three mutations, T2Q, N8D, and N37D, to guarantee an intact covalent chain at all pH values. The stability of the protein shows d...
Protein-based (bio) materials improves the storage and operational stability of graphene-based enzymatic biosensors.
Protein thermodynamics are an integral determinant of viral fitness and one of the major drivers of protein evolution. Mutations in the influenza A virus (IAV) hemagglutinin (HA) protein can eliminate neutralizing antibody binding to mediate escape from preexisting antiviral immunity. Prior research on the IAV nucleoprotein suggests that protein stability may constrain seasonal IAV evolution; h...
Objective(s):Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. One of the hallmarks of AD is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. In this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in AD and tauopathies. Unfortunately, the available syntheti...
We develop a mathematical model that describes concentration dynamics of PrP (Prion Protein Cellular) and Scrapie) prion proteins at the neuron scale includes effect unfolded protein response (UPR). first introduce single taking UPR mechanism into account. investigate it propose stability study among which bifurcation analysis with respect to three its parameters. Then, we generalize two neuron...
Our goal was to gain a better understanding of the contribution of the burial of polar groups and their hydrogen bonds to the conformational stability of proteins. We measured the change in stability, Δ(ΔG), for a series of hydrogen bonding mutants in four proteins: villin headpiece subdomain (VHP) containing 36 residues, a surface protein from Borrelia burgdorferi (VlsE) containing 341 residue...
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