Chronic hepatitis B virus (HBV) infection is one of the most associated factors in hepatocarcinogenesis. HBV is able to integrate into the host genome and encode the multi-functional hepatitis B virus x protein (HBx). Although the mechanism between HBx and carcinogenesis is still elusive, recent studies have shown that HBx was able to influence various signaling pathways, as well as epigenetic ...

The BAX gene is characterized by 5 protein coding transcripts (alpha/psi, beta, delta, epsilon, sigma). Baxbeta encodes the longest isoform (891 bp) of the gene. BAX-alpha/Bax-psi variant is 888 bp in length and codes for a protein isoform that possesses a shorter and different C terminus, as compared with the isoform BAX-beta. The third variant (BAX-delta), which is 741 bp in length, lacks exo...

Three papers published recently in Cell bring the power of human genetics, Drosophila genetics, and genomics to bear on the understanding of fragile X syndrome. They provide further support for the importance of local protein synthesis within a neuron as a determinant of proper synaptogenesis and the development of cognitive abilities.

a series of two experiments was conducted to study the optimum dietary protein level and protein to energy ratio of lemon fin barb hybrid larvae. in experiment 1, five isocaloric diets (4700 kcal per kg) ranging from 40 to 60% protein in 5% increments were fed to triplicate groups of lemon fin barb hybrid larvae (initial weight: 0.10 ± 0.01 mg per fish) for 21 days. weight gain of fish was prop...

The present study deals with the incorporation of 35S methionine into lens crystallins as a function of time after x-irradiation. Crystallin synthesis is first affected approximately 4 weeks following x-irradiation. This coincides with the time period at which the ratio of the two cations in the lens is affected, as shown in earlier studies. A greater decrease in 35S-methionine incorporation in...

Using the three-dimensional structure of biological macromolecules to infer how they function is one of the most important fields of modern biology. The availability of atomic resolution structures provides a deep and unique understanding of protein function, and helps to unravel the inner workings of the living cell. To date, 86% of the Protein Data Bank (rcsb-PDB) entries are macromolecular s...

PAGES I. Illtroductiorl.. .......................................................... 134 II. The Nature of X-Ray DifTraction. ....................................... 135 1. Diffraction from a Crystal ............................................ I35 a. Crystal Lattice and Reciprocal Lattice. ............................ 137 b. Structure Determination ........................................... I...

The X-ray study of protein crystals is a difficult and highly specialized field. Eventually, when the structure of a few proteins has been unraveled, the results will be of vital interest to ensytiologists, since they should give information about the spatial arrangement of the “active site” of the enzyme. But meanwhile X-ray methods will have only a secondary interest for enzymologists. The eq...

Multi-electrophilic yet compact, the rigid α-methylene-β-lactone (MeLac) warhead creates new opportunities to probe live-cell proteome. The MeLac reacts with five types of nucleophile on all seven classes enzymes. Protein structures show reacting residues in red and blue. On upper left, a protein directs tethering an affinity ligand (yellow) probe. More information can be found full paper by X....

This study was conducted to determine in vitro crude protein degradation (IVDP) parameters and effective crude protein degradability (EPD) of various feeds using the modified in vitro gas production (GP) technique. Feed samples were alfalfa hay, soybean meal, soybean, rapeseed meal, sunflower meal and fish meal. Rumen fluid was collected before the morning feeding from four rumen fistulated lam...