Porcine Reproductive and Respiratory Syndrome virus (PRRSv) can cause significant production losses due to reproductive failure including abortions, stillbirth, and premature farrowings. In growing pigs, it can cause increased mortality and decreased growth performance and increased number of cull pigs. The economic impact of an acute PRRSv outbreak in the breeding herd was estimated at USD $25...

Genotyping 42 serum samples taken from the pigs in the oubreaks from 2009 to 2013 with RT-PCR and nested RT-PCR, showed more than 80% of samples were positive with Chinese PRRSV clade, and the others were European and North American classical PRRSV genotypes. Ten serum samples from unnapprent PRRS herds were examined for antibodies against PRRSV with ELISA and also for PRRSV with RT-PCR. It was...

The objectives of this study were to compare the molecular and biological characteristics of recent porcine reproductive and respiratory syndrome virus (PRRSV) field isolates to those of a modified live virus (MLV) PRRS vaccine and its parent strain. One hundred seventeen, 4-week-old pigs were randomly assigned to six groups. Group 1 (n = 20) served as sham-inoculated negative controls, group 2...

BACKGROUND PRRS is a viral disease of pigs and sows that is one of the most costly to the pig industry worldwide. The disease can be controlled by focusing on different aspects. One of them is the vaccination of piglets, which is more controversial and difficult to manage than the vaccination of sows. However, pig producers could consider a piglet vaccination strategy if it reduces the negative...

The control of porcine reproductive and respiratory syndrome (PRRS) is still a major issue worldwide in the pig farming sector. Despite extensive research efforts practical experience gained so far, severely affects farmed pigs challenges established beliefs veterinary virology immunology. clinical economic repercussions PRRS are based on concomitant, additive features virus pathogenicity, host...

Innate immunity is an ancient form of host defense that is shared by almost all multicellular organisms (1, 2). However, it is not a redundant defense mechanism, and recent evidence has shown that innate immunity not only provides a first line of antimicrobial host defense, but also has a profound impact on the establishment of adaptive immune responses (1, 3). Upon infection, microorganisms ar...

A large challenge experiment using North American porcine reproductive and respiratory virus (PRRSV-2) provided new insights into the pathophysiology of reproductive PRRS. Deep phenotyping of dams and fetuses identified maternal and fetal predictors of PRRS severity and resilience. PRRSV infection resulted in dramatic decreases in all leukocyte subsets by 2days post inoculation. Apoptosis in th...

• PRRS virus infection can result in financial losses due to increased death loss, poor reproductive performance, an increased significance of other diseases, increased use of vaccines and medications, and increased diagnostic costs. • Acute outbreaks in breeding herds have been estimated to be around $250 per sow with some estimates as high as $302 per sow. • Costs associated with persistent i...

and Implications The results of this research suggest: (1) PRRSV has a detrimental effect on the uptake of copper particles by pulmonary intravascular macrophages (PIMs), (2) the severity of PRRSV-induced damage to PIMs differs among PRRSV isolates, and (3) PRRSV-induced decreased pulmonary clearance supports the hypothesis that PRRSV infection makes pigs more susceptible to bacterial septicemia.