As one of the most troublesome complications in patients with chronic renal disease, the etiology of uremic pruritus remains unknown, and the current therapeutic approaches are limited and unsatisfactory. To identify potential biomarkers for improving diagnosis and treatment and obtain a better understanding of the pathogenesis of uremic pruritus, we compared serum metabolome profiles of severe...

INTRODUCTION Pruritus is one of the most common cutaneous complications in hemodialysis patients. There is no consensus on etiologic and pathologic factors. This study is aimed to evaluate the correlation between serum intact parathyroid hormone (PTH) level and the severity of pruritus in hemodialysis patients. MATERIALS AND METHODS In a cross-sectional study, all of the patients referred to ...

OBJECTIVES To determine the safety and efficacy of rifampin for treatment of pruritus associated with cholestasis due to chronic liver disease. METHODS Medical literature was searched systematically using keywords as rifampicin, rifampin, rifamycin, cholestasis, pruritus, itching, and liver disease. Trials that compared the efficacy of rifampin with placebo/alternative for treatment of prurit...

INTRODUCTION Pruritus is the most common skin disorder in the geriatric population.1 It is defined as an unpleasant cutaneous sensation that provokes the desire to scratch.2 Acute itch (lasting less than 6 weeks) may provide a protective function, but chronic itch (lasting more than 6 weeks) is mostly a nuisance.3 The prevalence of pruritus increases with age and can be partially attributed to ...

BACKGROUND Pruritus is a characteristic clinical sign of allergic skin conditions including atopic dermatitis (AD) in the dog. IL-31 is a cytokine found in the serum of some dogs with AD and can induce pruritic behaviours in laboratory beagle dogs. HYPOTHESIS/OBJECTIVES The objectives were to characterize an IL-31-induced pruritus model by evaluating the efficacy of prednisolone, dexamethason...

INTRODUCTION AND OBJECTIVE While pruritus is a common complication in hemodialysis patients, the pathophysiological mechanisms remain obscure. Recently, B-type (brain) natriuretic peptide (BNP) has been defined as an itch-selective neuropeptide in pruriceptive neurons in mice, and higher serum levels of BNP are frequently observed in hemodialysis patients. The objective of the present study was...