نتایج جستجو برای: pseudo tau essential

تعداد نتایج: 426824  

2014
Anthony L. Petraglia Benjamin A. Plog Samantha Dayawansa Matthew L. Dashnaw Katarzyna Czerniecka Corey T. Walker Michael Chen Ollivier Hyrien Jeffrey J. Iliff Rashid Deane Jason H. Huang Maiken Nedergaard

BACKGROUND An animal model of chronic traumatic encephalopathy (CTE) is essential for further understanding the pathophysiological link between repetitive head injury and the development of chronic neurodegenerative disease. We previously described a model of repetitive mild traumatic brain injury (mTBI) in mice that encapsulates the neurobehavioral spectrum characteristic of patients with CTE....

Journal: :Human molecular genetics 2012
Yousuf O Ali Kai Ruan R Grace Zhai

Tauopathies, including Alzheimer's disease, are a group of neurodegenerative diseases characterized by abnormal tau hyperphosphorylation that leads to formation of neurofibrillary tangles. Drosophila models of tauopathy display prominent features of the human disease including compromised lifespan, impairments of learning, memory and locomotor functions and age-dependent neurodegeneration visib...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1994
C A Callahan J B Thomas

The most commonly used enzymatic reporter molecule, Escherichia coli beta-galactosidase (beta-gal; beta-D-galactoside galactohydrolase, EC 3.2.1.23), fails to readily diffuse into axons; consequently, the morphologies of beta-gal-labeled neurons cannot directly be determined. For analysis of neuronal pathfinding and synaptic connectivity, this information is essential. We have constructed an ax...

2012
Saar Oz Yanina Ivashko-Pachima Illana Gozes

Microtubules (MTs), key cytoskeletal elements in living cells, are critical for axonal transport, synaptic transmission, and maintenance of neuronal morphology. NAP (NAPVSIPQ) is a neuroprotective peptide derived from the essential activity-dependent neuroprotective protein (ADNP). In Alzheimer's disease models, NAP protects against tauopathy and cognitive decline. Here, we show that NAP treatm...

Journal: :The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001
J R Thorpe S J Morley S L Rulten

The human parvulin Pin1 is a member of the peptidyl-prolyl cis-trans isomerase group of proteins, which modulate the assembly, folding, activity, and transport of essential cellular proteins. Pin1 is a mitotic regulator interacting with a range of proteins that are phosphorylated before cell division. In addition, an involvement of Pin1 in the tau-related neurodegenerative brain disorders has r...

Journal: :Physical review letters 2009
B Aubert Y Karyotakis J P Lees V Poireau E Prencipe X Prudent V Tisserand J Garra Tico E Grauges M Martinelli A Palano M Pappagallo G Eigen B Stugu L Sun M Battaglia D N Brown L T Kerth Yu G Kolomensky G Lynch I L Osipenkov K Tackmann T Tanabe C M Hawkes N Soni A T Watson H Koch T Schroeder D J Asgeirsson B G Fulsom C Hearty T S Mattison J A McKenna M Barrett A Khan A Randle-Conde V E Blinov A D Bukin A R Buzykaev V P Druzhinin V B Golubev A P Onuchin S I Serednyakov Yu I Skovpen E P Solodov K Yu Todyshev M Bondioli S Curry I Eschrich D Kirkby A J Lankford P Lund M Mandelkern E C Martin D P Stoker H Atmacan J W Gary F Liu O Long G M Vitug Z Yasin V Sharma C Campagnari T M Hong D Kovalskyi M A Mazur J D Richman T W Beck A M Eisner C A Heusch J Kroseberg W S Lockman A J Martinez T Schalk B A Schumm A Seiden L Wang L O Winstrom C H Cheng D A Doll B Echenard F Fang D G Hitlin I Narsky P Ongmongkolkul T Piatenko F C Porter R Andreassen G Mancinelli B T Meadows K Mishra M D Sokoloff P C Bloom W T Ford A Gaz J F Hirschauer M Nagel U Nauenberg J G Smith S R Wagner R Ayad W H Toki R J Wilson E Feltresi A Hauke H Jasper T M Karbach J Merkel A Petzold B Spaan K Wacker M J Kobel R Nogowski K R Schubert R Schwierz D Bernard E Latour M Verderi P J Clark S Playfer J E Watson M Andreotti D Bettoni C Bozzi R Calabrese A Cecchi G Cibinetto E Fioravanti P Franchini E Luppi M Munerato M Negrini A Petrella L Piemontese V Santoro R Baldini-Ferroli A Calcaterra R de Sangro G Finocchiaro S Pacetti P Patteri I M Peruzzi M Piccolo M Rama A Zallo R Contri E Guido M Lo Vetere M R Monge S Passaggio C Patrignani E Robutti S Tosi K S Chaisanguanthum M Morii A Adametz J Marks S Schenk U Uwer F U Bernlochner V Klose H M Lacker T Lueck A Volk D J Bard P D Dauncey M Tibbetts P K Behera M J Charles U Mallik J Cochran H B Crawley L Dong V Eyges W T Meyer S Prell E I Rosenberg A E Rubin Y Y Gao A V Gritsan Z J Guo N Arnaud J Béquilleux A D'Orazio M Davier D Derkach J Firmino da Costa G Grosdidier F Le Diberder V Lepeltier A M Lutz B Malaescu S Pruvot P Roudeau M H Schune J Serrano V Sordini A Stocchi G Wormser D J Lange D M Wright I Bingham J P Burke C A Chavez J R Fry E Gabathuler R Gamet D E Hutchcroft D J Payne C Touramanis A J Bevan C K Clarke F Di Lodovico R Sacco M Sigamani G Cowan S Paramesvaran A C Wren C L Davis A G Denig M Fritsch W Gradl A Hafner K E Alwyn D Bailey R J Barlow G Jackson G D Lafferty T J West J I Yi J Anderson C Chen A Jawahery D A Roberts G Simi J M Tuggle C Dallapiccola E Salvati R Cowan D Dujmic P H Fisher S W Henderson G Sciolla M Spitznagel R K Yamamoto M Zhao P M Patel S H Robertson M Schram P Biassoni A Lazzaro V Lombardo F Palombo S Stracka L Cremaldi R Godang R Kroeger P Sonnek D J Summers H W Zhao M Simard P Taras H Nicholson G De Nardo L Lista D Monorchio G Onorato C Sciacca G Raven H L Snoek C P Jessop K J Knoepfel J M Losecco W F Wang L A Corwin K Honscheid H Kagan R Kass J P Morris A M Rahimi S J Sekula Q K Wong N L Blount J Brau R Frey O Igonkina J A Kolb M Lu R Rahmat N B Sinev D Strom J Strube E Torrence G Castelli N Gagliardi M Margoni M Morandin M Posocco M Rotondo F Simonetto R Stroili C Voci P Del Amo Sanchez E Ben-Haim G R Bonneaud H Briand J Chauveau O Hamon Ph Leruste G Marchiori J Ocariz A Perez J Prendki S Sitt L Gladney M Biasini E Manoni C Angelini G Batignani S Bettarini G Calderini M Carpinelli A Cervelli F Forti M A Giorgi A Lusiani M Morganti N Neri E Paoloni G Rizzo J J Walsh D Lopes Pegna C Lu J Olsen A J S Smith A V Telnov F Anulli E Baracchini G Cavoto R Faccini F Ferrarotto F Ferroni M Gaspero P D Jackson L Li Gioi M A Mazzoni S Morganti G Piredda F Renga C Voena M Ebert T Hartmann H Schröder R Waldi T Adye B Franek E O Olaiya F F Wilson S Emery L Esteve G Hamel de Monchenault W Kozanecki G Vasseur Ch Yèche M Zito M T Allen D Aston R Bartoldus J F Benitez R Cenci J P Coleman M R Convery J C Dingfelder J Dorfan G P Dubois-Felsmann W Dunwoodie R C Field M Franco Sevilla A M Gabareen M T Graham P Grenier C Hast W R Innes J Kaminski M H Kelsey H Kim P Kim M L Kocian D W G S Leith S Li B Lindquist S Luitz V Luth H L Lynch D B Macfarlane H Marsiske R Messner D R Muller H Neal S Nelson C P O'Grady I Ofte M Perl B N Ratcliff A Roodman A A Salnikov R H Schindler J Schwiening A Snyder D Su M K Sullivan K Suzuki S K Swain J M Thompson J Va'vra A P Wagner M Weaver C A West W J Wisniewski M Wittgen D H Wright H W Wulsin A K Yarritu C C Young V Ziegler X R Chen H Liu W Park M V Purohit R M White J R Wilson M Bellis P R Burchat A J Edwards T S Miyashita S Ahmed M S Alam J A Ernst B Pan M A Saeed S B Zain A Soffer S M Spanier B J Wogsland R Eckmann J L Ritchie A M Ruland C J Schilling R F Schwitters B C Wray B W Drummond J M Izen X C Lou F Bianchi D Gamba M Pelliccioni M Bomben L Bosisio C Cartaro G Della Ricca L Lanceri L Vitale V Azzolini N Lopez-March F Martinez-Vidal D A Milanes A Oyanguren J Albert Sw Banerjee B Bhuyan H H F Choi K Hamano G J King R Kowalewski M J Lewczuk I M Nugent J M Roney R J Sobie T J Gershon P F Harrison J Ilic T E Latham G B Mohanty E M T Puccio H R Band X Chen S Dasu K T Flood Y Pan R Prepost C O Vuosalo S L Wu

We search for a light Higgs boson A0 in the radiative decay Upsilon(3S)-->gammaA(0), A(0)-->tau+tau-, tau+-->e+nu(e)nu(tau), or tau+-->mu+nu(mu)nu(tau). The data sample contains 122x10(6) Upsilon(3S) events recorded with the BABAR detector. We find no evidence for a narrow structure in the studied tau+tau- invariant mass region of 4.03<m(tau+tau-)<10.10 GeV/c2. We exclude at the 90% confidence ...

Journal: :The Journal of General Physiology 1985
M Mahler

In frog sartorius muscle, after a tetanus at 20 degrees C, during which an impulse-like increase occurs in the rate of ATP hydrolysis, the rate of O2 consumption (QO2) reaches a peak relatively quickly and then declines monoexponentially, with a time constant not dependent on the tetanus duration (tau = 2.6 min in Rana pipiens and 2.1 min in Rana temporaria). To a good approximation, these kine...

2014
Liang Peng Ruodu Wang

Copula models have been popular in risk management. Due to the properties of asymptotic dependence and easy simulation, the t-copula has often been employed in practice. A computationally simple estimation procedure for the t-copula is to first estimate the linear correlation via Kendall’s tau estimator and then to estimate the parameter of the number of degrees of freedom by maximizing the pse...

Let $X$ be a Banach space of $dim X > 2$ and $B(X)$ be the space of bounded linear operators on X. If $L : B(X)to B(X)$ be a Lie higher derivation on $B(X)$, then there exists an additive higher derivation $D$ and a linear map $tau : B(X)to FI$ vanishing at commutators $[A, B]$ for all $A, Bin B(X)$ such that $L = D + tau$.

Journal: :bulletin of the iranian mathematical society 0
a. ebadian department of mathematics, payame noor university, p.o. box 19395-3697, tehran, iran. s. rahrovi department of mathematics, faculty of basic science, university of bonab, p.o. box 5551-761167, bonab, iran. s. shams department of mathematics‎, ‎urmia university, urmia‎, ‎iran. j. sokol department of mathematics‎, ‎rzesz&amp;#039;ow university of technology‎, ‎poland‎.

‎we determine the‎ ‎form of polynomially bounded solutions to the loewner differential ‎equation that is satisfied by univalent subordination chains of the‎ ‎form $f(z,t)=e^{int_0^t a(tau){rm d}tau}z+cdots$‎, ‎where‎ ‎$a:[0,infty]rightarrow l(mathbb{c}^n,mathbb{c}^n)$ is a locally‎ ‎lebesgue integrable mapping and satisfying the condition‎ ‎$$sup_{sgeq0}int_0^inftyleft|expleft{int_s^t‎ ‎[a(tau)...

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