نتایج جستجو برای: pteridine reductase 1
تعداد نتایج: 2784388 فیلتر نتایج به سال:
Activation of the polyol pathway has been linked to the development of secondary diabetic complications. However, the underlying molecular mechanisms remain unclear. To probe the contribution of this pathway, we examined whether inhibition of aldose reductase, which catalyzes the first step of the pathway, affects hyperglycemia-induced activation of the inflammatory transcription factor nuclear...
Aldo-keto reductase family 1 member C3 has recently been regarded as a potential therapeutic target in castrate-resistant prostate cancer. Herein, we investigated whether berberine delayed the progression of castrate-resistant prostate cancer by reducing androgen synthesis through the inhibition of Aldo-keto reductase family 1 member C3. Cell viability and cellular testosterone content were mea...
Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis. Mouse livers lacking both TrxR1 and Gsr sustain these essential activities using an N...
aldose reductase is a critical enzyme in the polyol pathway that plays an important role in diabetes mellitus. inhibition of the activity of this enzyme can prevent cataract in diabetic patients’lenses. in this study the inhibitory effect of two flavonoids, quercetin and naringin, in the activity of aldose reductase in streptozotocin-induced diabetic and healthy rats were investigated. thirty m...
A method for the fluorometry of singlet oxygen ((1)O(2)) using less fluorescent folic acid and its analogue, methotrexate (MTX), was examined. Folic acid and MTX were decomposed into a strongly fluorescent pteridine compound via a photosensitized reaction by (1)O(2)-generating photosensitizers in a deuterium oxide solution. The fluorescence intensity increased in proportion to the irradiation t...
H umans require a minimum daily intake of essential micronutrients, vitamins, and minerals to maintain optimal health. Micronutrient malnutrition, the dietary insufficiency of one or more micronutrients, has far-reaching negative health consequences at all stages of life and was a pervasive health issue for all countries at the turn of the 20th century. Micronutrient malnutrition has been signi...
background: the association between methylene tetrahydrofolate reductase polymorphism and coronary artery diseases risk has been both confirmed and refuted in a number of published studies. the aim of this study was to investigate whether genetic polymorphisms of mthfr (c677t, a1298c) contributed to the development of myocardial infarction (mi). materials and methods: the present case-control s...
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