C LASSICAL studies of atrial defect1' 2 have mentioned only the total pulmonary blood flow and the appearance of pulmonary plethora on the chest radiograph. No mention has been made of differences between the two lungs. The present study was suggested by investigations on the first patient in this series. He was a 50-year-old man whose atrial septal defeet was confirmed by cardiac catheterizati...

Exposure to acute hypoxia (barometric pressure 263 mmHg) for 8 hours did not lead to increased numbers of mast cells in the lungs of rats. In contrast, in adult rats kept for 35 days at a barometric pressure of 380 mmHg there was a proliferation of mast cells around the pulmonary blood vessels and in the alveolar septa. This hyperplasia of lung mast cells in response to chronic hypoxia was reve...

C LASSICAL studies of atrial defect1' 2 have mentioned only the total pulmonary blood flow and the appearance of pulmonary plethora on the chest radiograph. No mention has been made of differences between the two lungs. The present study was suggested by investigations on the first patient in this series. He was a 50-year-old man whose atrial septal defeet was confirmed by cardiac catheterizati...

C LASSICAL studies of atrial defect1' 2 have mentioned only the total pulmonary blood flow and the appearance of pulmonary plethora on the chest radiograph. No mention has been made of differences between the two lungs. The present study was suggested by investigations on the first patient in this series. He was a 50-year-old man whose atrial septal defeet was confirmed by cardiac catheterizati...

Blood vessels are the way for nutrients present outside the brain to gain access into the cerebral parenchyma. When neurons are diseased, for example by toxin exposure, reactive glial cells secrete local factors that induce microangiogenesis, probably as part of a spontaneous neuroprotective mechanism related to the increased metabolic demand. In Parkinson's disease (PD) and non human primate m...

Structural changes in the pulmonary circulation were studied in the lungs of 5 infants dying with ventricular septal defect. Applying precise quantitative morphological techniques to the pulmonary vessels, it was possible to correlate pathological change with clinical and haemodynamic findings, and to identify two patterns of response. Three of the infants (group I) ppresnted in cardiac failure...

Pulmonary capillary hemangiomatosis (PCH) is a rare idiopathic lung disorder that occurs in young patients and leads to pulmonary hypertension (PH). It is difficult to diagnosis in the early stage and is often mistaken for primary PH; in almost all cases of PCH, the correct diagnosis is not made until autopsy. In the present case of PCH, the patient had severe pulmonary hypertension and died of...

PULMONARY ARTERIAL HYPERTENSION (PAH) is a rare human disease displaying a very poor prognosis of survival. The chronic increase in pulmonary vascular resistance associated with PAH eventually leads to right ventricular hypertrophy and failure, and ultimately death. It is well accepted that the increase in pulmonary arterial resistance to blood flow in PAH primarily involves a partial or comple...

Fig. 1. Upper left oblique view using a volume rendering technique from heart and great vessels. Ascending aorta (AA) is medial and gives rise first to left carotid artery (LCA), then to right carotid artery (RCA) and right subclavian artery (RSCA), left subclavian artery (LSCA) arising from the upper part of the descending aorta. The aortic arch is right sided (RAA) and its distal portion is v...

Metastatic calcification is commonly associated with multiple myeloma, presumably because this disorder has a propensity for causing hypercalcaemia and renal failure. Pathologically, the most common sites of calcium deposition are the lung, kidney, gastric mucosa, heart, and blood vessels.' Metastatic pulmonary calcification is rarely detected radiographically, and when it is other pulmonary ab...