Mineral trioxide aggregate (MTA) is a powder containing calcium silicate composed of hydrophilic particles which harden at the presence of moisture. MTA was initially introduced as a root end filling material. Due its practical advantages that include superior biocompatility, effective sealing capability, and the ability to improve regeneration of the pulp and peripheral root tissues, it is use...

There is no consensus on the true meaning of clinical regenerative endodontics, and there confusion over concept term. Commonly used terms include revitalization revascularization. The methods for endodontic procedures tissue engineering differ depending whether exogenous delivery cells – called cell therapy, or not. Here, in this review, difference clarified by emphasizing correct terminology:...

Currently, minimally invasive restorations could be made in dentistry applying adhesive materials and adhesion principles to the dental structures. Following this philosophy, endodontic interventions have been avoided largely, preserving hard tissues, maintaining vitality. Advances biologically favorable bioactive enabled clinicans induce repair regeneration of tissues. Such are primarily used ...

Innate immunity represents the first line of defence against infectious agents and is essential for the detection of pathogens invading the host. Unless adaptive immunity, innate immunity is considered as non-specific as it is antigen-independent and reacts similarly to a variety of micro-organisms. It is responsible for mounting potent inflammatory responses that bring to infected tissues a va...

Abstract Background Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators injury response, stem cells (DPSCs) play a critical role in repair regeneration. Resolvin E1 (RvE1), major dietary omega-3 polyunsaturated fatty-acid metabolite, is effective resolving activating wound healing. However, whether RvE1 facilitates injure...

To heal or not to heal? Chemokines as determinants of constructive or destructive inflammatory microenvironments Dear Readers, Dental pulp stem cells gained attention as a subpopulation of postnatal stem cells with the ability of multipotential differentiation. Therefore, these cells, specifically SHED (stem cells from human exfoliated deciduous teeth), have been extensively investigated as a p...

INTRODUCTION Endodontic-periodontal combined lesion is a clinical dilemma because making a differential diagnosis and deciding a prognosis are difficult. METHODS Twenty-six cases from 14 articles involving the successful management of endodontic-periodontal lesions with concurrent regenerative procedures were reviewed. This article also presents successful treatment of an endodontic-periodont...

Cutaneous nerve regeneration following toe-to-finger transplantation was studied by immunohistochemical technique using antibody to protein gene product 9.5 (PGP 9.5) which is a specific neuronal marker. By this technique, epidermal and dermal nerves were semi-quantified and the Meissner's corpuscles were quantified. There were also quantitative sensory tests (QST) including pinprick, pressure ...

The development of biomaterials capable of driving dental pulp stem cell differentiation into odontoblast-like cells able to secrete reparative dentin is the goal of current conservative dentistry. In the present investigation, a biomembrane (BM) composed of a chitosan/collagen matrix embedded with calcium-aluminate microparticles was tested. The BM was produced by mixing collagen gel with a ch...