Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia, followed by sight threatening pathologic neovascularization in the second phase. Previously we found that Sirtuin1 (Sirt1), a metabolically de...

PURPOSE We aimed to assess the agreement between clinical assessment of diabetic retinopathy and Optomap ultrawide-field imaging (UWFI) in a real-life clinic setting. METHODS Structured examination findings, from diabetic patients attending routine medical retina clinics in July 2011, were retrospectively compared with the grade obtained from Optomap UWFI images, graded independently by two o...

Currently the “pandemic” of diabetes mellitus is noted. The incidence and prevalence diabetic retinopathy, most common microvascular complications diabetes, are exponentially growing due to increased life expectancy in many parts world. increasing number people suffering from retinopathy not only highlights medical issues, but also an economic burden, representing a social challenge. It extreme...

OBJECTIVE To study insulin dependent diabetic patients for change in non-proliferative retinopathy and its relation to glycaemic control and to various clinical background data. DESIGN Prospective study with follow up for seven years. SETTING Outpatient departments of university hospitals. MAIN OUTCOME MEASURES Glycated haemoglobin concentration; degree of retinopathy. RESULTS Retinopat...

OBJECTIVE Increasing evidence suggests that macrovascular disease and retinopathy may be more closely linked than previously believed. We determined the relationship between retinopathy and coronary atherosclerosis as measured by computed tomography-detectable coronary artery calcium (CAC). RESEARCH DESIGN AND METHODS The cross-sectional association between CAC and retinopathy was assessed on...

It has been suggested that joint contractures may be an early marker of microangiopathy, especially retinopathy, in diabetic patients. To investigate this possibility, the prevalence of contractures of the finger joints, as assessed by the painted hand technique, was compared in 106 diabetic patients without, and 105 with retinopathy (proliferative in 66%). There was an increased prevalence of ...

We investigated the association of serum homocysteine levels and vitamin status with type 2 diabetic retinopathy. This study included 65 patients with and 75 patients without diabetic retinopathy. Patients with diabetic retinopathy had significantly higher serum homocysteine levels (P < 0.001), higher prevalence of hyperhomocysteinemia (P < 0.001), lower serum folic acid (P < 0.001), and vitami...

purpose: to describe the prevalence and risk factors of diabetic retinopathy (dr) in adults aged 40-80 years in yazd province in 2011. methods: this is a population-based survey on 2,320 urban and rural residents of yazd province. random multi-stage cluster sampling was employed in the survey. diagnosis of diabetes was made upon past medical history and drug history or insulin injection and in ...

Abstract In this presentation, a case of bilateral choroidal folds in patient with diabetic retinopathy was reported. By our knowledge, this case presentation is the first report of choroidal folds in diabetic retinopathy, which bilateral symmetric and horizontal folds arranged in macula. The thick choroid that is developed in diabetics may be a cause of these folds but the source of differenc...

The prevalence of diabetes in pregnancy is increasing. Pre-existing diabetes is present in 1 in 167 pregnancies in Australia, divided equally between type 1 and type 2 diabetes. Diabetic retinopathy is a leading cause of blindness in women during their childbearing years, and pregnancy increases the short-term risk of diabetic retinopathy progression. We examine the risk factors for progression...