Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the...

Sir—Almost all available antiretroviral drugs can induce exanthema, but only a small number can cause life-threatening reactions [1, 2]. The drugs carrying the highest risk of causing severe cutaneous adverse reactions are nevirapine [3], efa-virenz [4], and the nucleoside analogue abacavir [5]. To our knowledge, no cases of acute generalized exanthematous pus-tulosis (AGEP) have been reported ...

Using a Potential Field Source Surface model (PFSS), we study magnetic field overlying erupted filaments in solar active regions. The filaments studied here were reported to experience a kink instability or a torus instability. The torus instability leads to a full eruption, while the kink instability leads to a full eruption or a failed eruption. It is found that for full eruption the field de...

Abstract An 8-year-old boy with epidermolytic ichthyosis (EI) due to a heterozygous KRT1 mutation presented striking bullous skin eruption. Microbiological swabs were sent, and oral antibiotics prescribed for suspected impetigo. He deteriorated clinically, developing fever more extensive pustular rash reminiscent of generalized psoriasis (GPP). Skin biopsies from two distinct cutaneous sites re...

BACKGROUND Severe forms of psoriasis can be complicated by systemic microvascular hyperpermeability. Vascular endothelial growth factor (VEGF) possesses potent vascular permeability activity. We suggest that VEGF enters the systemic circulation and acts on microvessels to mediate hyperpermeability. OBJECTIVES To quantify renal microvascular permeability and circulating VEGF concentration in s...

BACKGROUND CD39 and CD73 are two novel cell surface markers of CD25high Foxp3+ regulatory T-cells (Tregs). Concordant expression of these two ectoenzymes not only discriminate Tregs from other cell populations, but also generates pericellular adenosine, which has been reported to suppress proliferation of activated T effector (Teff) cells. Because it is currently unclear whether human ectoenzym...

Background and aims. Predicting the teeth eruption time is a valuable tool in pediatric dentistry since it can affects scheduling dental and orthodontic treatments. This study investigated the relationship between the eruption time of first primary and permanent teeth and the variation in the eruption time considering socioeconomic status (SES) in a 9-year population- based cohort study. Materi...

PURPOSE The purpose of this project was to establish median eruption ages of primary teeth and evaluate eruption differences between contralateral teeth by gender, ethnicity, and household income. Data was derived from a caries study of preschool children. METHODS A total of 4,277 white (non-Hispanic) and Hispanic preschool children from Arizona were visually examined for caries and tooth eru...

Correspondence Ronni Wolf, MD Dermatology Unit Kaplan Medical Center 76100 Rechovot Israel E-mail: [email protected] All authors evaluated the patient and histologic specimens, discussed the case, wrote parts of the manuscript, and reviewed and approved the final version of the paper. None of the authors have any relevant conflict of interests. Abstract A 76-year-old man developed a macul...