نتایج جستجو برای: pyrano2 3 dpyrimidine derivatives
تعداد نتایج: 1895539 فیلتر نتایج به سال:
Reactions of nine-atom deltahedral clusters (Zintl ions) of tin, Sn 9 (4-), with alkyl chlorides, RCl (R = (t) Bu, (n) Bu, (s) Bu), and alkynes (Me3Si-C[triple bond]C-SiMe3, Ph-C[triple bond]CH) yielded the corresponding alkylated and alkenylated clusters [Sn 9-R] (3-). The triple bonds of the alkynes are hydrogenated to double bonds in the process. These are the first tin-based organo-Zintl io...
5-(1,2,3,4-Tetrahydroxybutyl)-2-methylfuran-3-carbohydrazide (2) was condensed with a variety of ketones to afford carbohydrazide derivatives 3-6. Acetylation of 3-5 afforded the acetyl derivatives 7-9, while periodate oxidation of 3-6 afforded the formyl derivatives 10-13. Acid catalyzed condensation of thiosemicarbazide or o-tolylthiosemicarbazide with the prepared aldehydes 10-12 gave thiose...
(R)-4-((4-(((4-((tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol (TBPT), a serotonin-4 receptor partial agonist, is metabolized to two metabolites: an N-dealkylation product [(R)-3-(piperidin-4-ylmethoxy)-4-((tetrahydrofuran-3-yl)oxy)benzo[d]isoxazole (M1)] and a cyclized oxazolidine structure [7-(((4-(((R)-tetrahydrofuran-3-yl)oxy)benzo[...
In the present study it is demonstrated that MO-QSARs (quantitative structure activity relationships based on calculated molecular orbital substrate characteristics) of cytochrome P450-catalysed biotransformation of benzene derivatives obtained in previous studies for Wistar rats, can be extrapolated to other species, including man. First, it was demonstrated that the regioselectivity of the in...
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