نتایج جستجو برای: pyrazole derivative

تعداد نتایج: 66771  

2010
Hualing Zhu Jun Shi Zhen Wei Yanan Bai Luxia Bu

In the title compound, C(23)H(23)N(5)O(2), an intra-molecular N-H⋯O hydrogen bond generates an S(6) ring, and the dihedral angle between the pyrazole rings is 48.42 (8)°. The dihedral angles between the pyrazole rings and their attached phenyl rings are 10.06 (8) and 47.53 (8)°.

Journal: :Acta crystallographica. Section E, Crystallographic communications 2015
Shaaban K Mohamed Joel T Mague Mehmet Akkurt Mustafa R Albayati Alaa F Mohamed

In the title mol-ecule, C21H14N4O4, the phenyl rings make dihedral angles of 39.61 (8) and 9.4 (1)°, respectively, with the central pyrazole ring. The dihedral angle between the pyrazole and di-nitro-phenyl rings is 46.95 (5)°. In the crystal, mol-ecules pack in helical stacks parallel to the a axis aided by weak C-H⋯O inter-actions.

2010
Consuelo Escolástico Mercedes Blanco Rosa M. Claramunt Dionisia Sanz José Elguero

The synthesis under MW irradiation without solvent of 19 pyrazoles, of which only 8 were known, is described. They bear C-methyl groups and trityl, diphenylmethyl and benzyl groups at positions 1 and 4 of the pyrazole ring. In the reaction between pyrazole and trityl bromide an unexpected reaction occurred and 4-(9-phenyl-9H-fluoren-9-yl)-1Hpyrazole (7) was isolated.

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
Q Xie Q Y Zhang Y Zhang T Su J Gu L S Kaminsky X Ding

We have recently shown that rat CYP2J4 is inducible by pyrazole in liver, small intestine, and olfactory mucosa. The aim of the present study was to determine whether mouse CYP2Js are also inducible by pyrazole, which was known to induce CYP2A5 in mouse liver and kidney, but not in lung or olfactory mucosa. CYP2J proteins were detected in mouse liver, lung, kidney, heart, eye, olfactory mucosa,...

Highly substituted 1,4-dihydropyrano[2,3-c]pyrazole derivatives were synthesized by four-component reaction of aromatic aldehydes, malononitrile, ethyl acetoacetate and various phenylhydrazine, using nickel ferrite as a recyclable nanocatalyst by a grinding method under solvent-free and thermal conditions. The reaction has the advantages of good yields, less pollution, ease of separation of the...

Journal: :Chemical communications 2015
Deepak Chand Jean'ne M Shreeve

An efficient route to polyiodopyrazoles, 3,4,5-triiodopyrazole (1), 1-methyl-3,4,5-triiodopyrazole (2) and 1-diiodomethyl-3,4,5-triiodopyrazole (3), opens the door to prospective biocides. Nitration of 1 and 2 gives the previously inaccessible compounds, 3,4-dinitro-5-iodopyrazole (4), and 3,4-dinitro-5-iodo-1-methylpyrazole (5), respectively. These synthetic pathways will open many fronts for ...

The physical and chemical properties of Pyrazole and Pyrazoline molecules were theoreticallystudied by Gaussian 03, software with NMR and Molecular orbital calculations at B3LYP/6-31G andB3LYP/6-31+G(d) levels, in gas phase and solution. In this study a comparison effect of threesolvents with different dielectric constants on Pyrazole and Pyrazoline molecules in aspect energyinteraction between...

2016
ABDUL GHAFOOR NOREEN ASLAM MARK C. ELLIOTT

Pyrazoles are very important class of biologically active compounds and many of their derivatives are in clinical use. Pyrazole derivatives have been shown to exhibit antihyperglycemic [1], hypoglycemic [2] and fungicidal properties [3]. Some of them are also used as insecticides and herbicides [4,5]. Of the condensed pyrazoles, specially pyrano[2,3-c]pyrazole is a fused heterocycle comprising ...

Journal: :European Journal of Chemistry 2022

In-silico quantitative structure-activity relationship (QSAR) study was performed to develop a model on series of novel pyrazole derivatives containing acetamide moiety which exhibited considerable antiproliferative activity against human colorectal adenocarcinoma cell line HT-29. The obtained has correlation coefficient (r) 0.9693, squared (r2) 0.9395 and leave-one-out (LOO) cross-validation (...

Journal: :Berichte der deutschen chemischen Gesellschaft 1904

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