The present work reports an efficient synthesis of fluorinated pyridinium salts-based hydrazones under both conventional and eco-friendly ultrasound procedures. The synthetic approach first involves the preparation of halogenated pyridinium salts through the condensation of isonicotinic acid hydrazide (1) with p-fluorobenzaldehyde (2) followed by the nucleophilic alkylation of the resulting N-(...

A glycyrrhetate-containing amphiphile, MGP (1-[2-(methyl glycyrrhetate)-2-oxoethyl]pyridinium bromide), has been synthesized, and found to assemble into supramolecular helical nanofibers in chloroform/aromatic solvents, which are primarily driven by π-π stacking, van der Waals forces, and hydrophobic interactions. During the assembly process, MGP stacked into J-aggregates resulting in the seque...

Two 3D coordination polymers of Mn(II) with azide and bifunctional zwitterionic ligands bearing both carboxylate and tetrazolate groups, 1-(carboxylatomethyl)-3-(5-tetrazolato)pyridinium (L(1)) and 1-(carboxylatoethyl)-4-(5-tetrazolato)pyridinium (L(2)), were synthesized, and structurally and magnetically characterized. They are formulated as [Mn(3)(L(1))(2)(N(3))(4)(H(2)O)(2)](n)·4nH(2)O (1) a...

A 1,2-bis(pyridinium)ethane type axle containing a terpyridine chelate group, when combined with 24-membered crown ethers, forms [2]pseudorotaxanes, the stability of which can be controlled by coordination of metal ions with different geometries.

Indium tin oxide (ITO) is an attractive substrate for single-molecule electronics since it transparent while maintaining electrical conductivity. Although has been used before as a contacting electrode in studies, these studies have limited to the use of carboxylic acid terminal groups binding molecular wires ITO substrates. There thus need investigate other anchoring with potential effectively...

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent dopaminergic neurotoxin that causes biochemical, pharmacological, and pathological deficits in experimental animals similar to those seen in human parkinsonian patients. All of the deficits can be prevented by treating mice with selective inhibitors of monoamine oxidase B (MAO-B), including deprenyl, prior to MPTP administration. W...

This work presents the synthesis, volatility study and electrospray ionization mass spectrometry with energy-variable collision induced dissociation of the isolated [(cation)2(anion)](+) of a novel series of 2-alkyl-1-ethyl pyridinium based ionic liquids, [(2)CN-2(1)C2Py][NTf2]. Compared to the imidazolium based ionic liquids, the new ionic liquid series presents a higher thermal stability and ...

The ability of two alkyl pyridinium sponge toxin preparations (poly-APS and halitoxin) to form transient pores/lesions in cell membranes and allow transfection of plasmid cDNA have been investigated using HEK 293 cells. Poly-APS and halitoxin preparations caused a collapse in membrane potential, reductions in input resistance and increased Ca2+ permeability. At least partial recovery was observ...

Six new tricationic Ir(III) complexes of cyclometalating ligands derived from 1-methyl-2-(2'-pyridyl)pyridinium or 1-methyl-4-(2'-pyridyl)pyridinium are described. These complexes of the form [Ir(III)(C^N)2(N^N)](3+) (C^N = cyclometalating ligand; N^N = α-diimine) have been isolated and characterised as their PF6(-) and Cl(-) salts. Four of the PF6(-) salts have been studied by X-ray crystallog...

Despite many previous important contributions to the characterization of the liquid-liquid phase behavior of ionic liquids (ILs) plus water systems, a gap still exists as far as the effect of isomers (of ILs) is concerned. Therefore, in this work, a comprehensive study of the liquid-liquid equilibria between water and isomeric pyridinium-based ionic liquids has been performed. Atmospheric press...