Normal cardiovascular regulation requires intact baroreflex regulation. The efferent portion of the baroreflex arc, which is composed of parasympathetic and sympathetic nerves, is particularly important in this regard. Autonomic failure ensues when the efferent arc is interrupted. Neuronal degeneration within the brain or in the periphery,1,2 enzymatic defects in catecholamine synthesis,3 and a...

PURPOSE The bradycardia produced by pyridostigmine and physostigmine in an animal model of acute cardiac denervation was examined according to its relation to cholinesterase inhibition and sensitivity to block by cholinergic receptor antagonists. METHODS Cats were anaesthetised, vagotomised and propranolol-treated. Heart rate was continuously recorded. Erythrocyte cholinesterase activity of a...

the reaction between trimethylamine with propargyl bromide was studied and the structure of triethyl propargyl ammonium bromide was illustrated by 1hnmr, ir, and mass spectra.

Exposure to high levels of organophosphorus compounds (OP) can induce status epilepticus (SE) in humans and rodents via acute cholinergic toxicity, leading to neurodegeneration and brain inflammation. Currently there is no treatment to combat the neuropathologies associated with OP exposure. We recently demonstrated that inhibition of the EP2 receptor for PGE2 reduces neuronal injury in mice fo...