2083 Background: Second-line treatment in recurrent or progressive glioblastoma (GBM) has not yet been defined. Since in vitro and preclinical studies demonstrated a hyper-radiosensitivity of human malignant glioma cell lines to low doses fractionated radiotherapy (LD-FRT) and a synergism with chemotherapy, we performed a pilot study to evaluate the feasibility and efficacy of this approach. ...

BACKGROUND Awareness about antibiotic resistance depends on the attitudes and information about antibiotic resistance of both patients and physicians. Persons who practice self-medication are at high risk of also self-medicating with antibiotics. The purpose of the present study was to evaluate the awareness about antibiotic resistance by investigating the practice in a group of self-medication...

Energy plays an active role in sustainable development in Iran, both in the sustainable and the development aspects. This study aims to estimate the nexus of economic growth and the renewable energy in Iran during 1981-2012. We employ the Auto-Regressive Distributed Lag (ARDL) model to estimate a log-linear equation. The results suggest that renewable energy consumption is an insignificant driv...

are associated with CpG islands. A large proportion of In this paper we present the entire genomic segenes with a tissue-restricted expression pattern also quence as well as the cDNA sequence of two new hucontain CpG islands. An interesting feature of CpG man genes encoding the g subunit of the NAD-depenislands is that at least some are capable of initiating dent isocitrate dehydrogenase (H-IDH...

The purpose of this Position Stand is to provide guidance to professionals who counsel and prescribe individualized exercise to apparently healthy adults of all ages. These recommendations also may apply to adults with certain chronic diseases or disabilities, when appropriately evaluated and advised by a health professional. This document supersedes the 1998 American College of Sports Medicine...

Introduction: The CLL2-BAG trial had shown very favourable response and minimal residual disease (MRD) rates with a sequential treatment consisting of an optional bendamustine (B) debulking, followed by doublet combination obinutuzumab (G) venetoclax (V) [Cramer et al, Lancet Oncol. 2018]. Following these results, the triplet adding BTK inhibitor (BTK-I) acalabrutinib (A) was tested in CLL2-BAA...

Adrenoleukodystrophy (ALD) is an X-linked neurodegenerative disorder associated with progressive central demyelination and adrenal insufficiency1. It was first described by Siemerling and Creutzfeldt2 in 1923 as “bronzed sclerosing encephalomyelitis. In 1970, Biaw assigned the now generally used term adrenoleukodystrophy. It is believed to be peroxisomal disease and biochemically characterized ...

Sir, Sézary cell leukemia (SCL) has been described as a very rare variant of T-prolymphocytic leukemia (TPLL)1-4 with 11 cases reported. T-PLL is usually an aggressive, mature T-cell disorder accompanied by progressive lymphocytosis, splenomegaly, skin lesions and poor outcome.4 However, a few cases with an indolent course have been reported.3 Prolymphocytes of T-PLL show an irregular nuclear s...

Large variations in the boron isotopic composition of sedimentary environments make boron an attractive monitor of fluidrrock interactions during diagenesis. Studies of B in marine sediments have shown that preferential adsorption of B on clay minerals leaves pore waters enriched in B. During diagenesis, clay minerals recrystallize and incorporate B into Ž the mineral structure Spivack, A.J., P...

To the Editors: Shah et al. (1) reported on the cardiotoxicity of the histone deacetylase inhibitor Romidepsin (depsipeptide, FK228) administered weekly 3 q28, in 15 patients with metastatic neuroendocrine tumors. The study was terminated early due to a high number of ‘‘serious cardiac adverse events’’ comprising of one sudden death, asymptomatic grade 2 ventricular tachycardia in two patients,...