A series of Nـ alkyl 2ـ ketomethylquinoline derivatives were synthesis by reaction of benzoyl chloride derivatives with Nـ methyl quinaldine iodide in the presence of triethyl amine under microwave irradiation. Enaminone form of the product study by spectroscopy method. The result revealed the  Nـ alkyl 2ـ ketomethylquinoline the fixed enaminone tautomer.

TACN (1,4,7-triazacyclononane) derivatives with three 6-methoxy-2-quinolylmethyl or 1-isoquinolylmethyl moieties were examined as fluorescent zinc sensors. Upon the addition of zinc, 6-MeOTQTACN (5) exhibited a 9-fold fluorescence increase at 420 nm (λex = 341 nm, ϕZn = 0.070). Fluorescence enhancement is specific for zinc and cadmium, although cadmium induces smaller increases (ICd/I0 = 3.6 an...

Dengue virus causes dengue fever, a debilitating disease with an increasing incidence in many tropical and subtropical territories. So far, there are no effective antivirals licensed to treat this virus. Here we describe the synthesis and antiviral activity evaluation of two compounds based on the quinoline scaffold, which has shown potential for the development of molecules with various biolog...

Copper(I) and nickel(0) complexes catalyze the formal [4 + 2] cycloaddition reactions of 1,2-diazines and siloxyalkynes, a reaction hitherto best catalyzed by silver salts. These catalysts based on earth abundant metals are not only competent, but the copper catalyst, in particular, promotes cycloadditions of pyrido[2,3-d]pyridazine and pyrido[3,4-d]pyridazine, enabling a new synthesis of quino...

Application of a dynamic microwave power system in the chemical synthesis of some phenothiazine and quinoline derivatives is described. Heterocyclic ring formation, aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensation reactions were performed on solid support, or under solvent free reaction conditions. The microwave-assisted Duff formylation of phenothiazine was ac...

Prompted by our discovery of a new class of conformationally-locked indeno[2,1-c]quinolines as anti-mycobacterials, compounds 2a and 3a (Fig. 1; MIC < 0.39 μg mL(-1) and 0.78 μg mL(-1), respectively)(14) with a freely rotating C2-imidazolo substituent, we herein describe the synthesis of pentacyclic azole-fused quinoline derivatives 4 and 5, in which we have restricted the rotation of the C2-im...

a simple and efficient method for the synthesis of quinolines and polycyclic quinolines using li+ modified nanoporous na+-montmorillonite is described. this new nanocatalyst proceeds via friedlander annulation under solvent-free conditions. it describes our observations about a trend of catalytic activity of lithium cation in nanoporous na+-montmorillonite. in this study, several types of 1,3-d...

quinolines, an important class of potentially bioactive compounds, have been synthesized by treatment of o-aminoarylketones and carbonyl compounds utilizing niobium (v) chloride / polyethylenglycole(nbcl5.peg) and niobium(v)chloride (nbcl5) as available and inexpensive catalysts. the quinoline derivatives were prepared in glycerol, an excellent solvent in terms of environmental impact, with hig...