The title compound, C(10)H(13)ClN(2)O, was obtained as a by-product in the reaction of 2-chloro-methyl-1H-benzimidazole, dimethyl sulfate and toluene to synthesise 2-chloro-methyl-1-methyl-benzimidazole. The dihedral angle between the benzene ring and the acetamide group is 89.72  (6)° while that between the aromatic ring and the chloracetyl group is 84.40 (4)°. In the crystal, adjacent mol-ecu...

In the title polymeric compound, [Mn(N(3))(2)(C(13)H(11)N(3))(2)](n), each Mn(II) centre is six-coordinated in an octahedral geometry by six N atoms from four 1-(4-pyridylmeth-yl)-1H-benzimidazole (L) ligands and two azide anions (N(3) (-)). Each of the Mn(II) ions lies on an inversion centre. The L ligands and N(3) (-) anions bridge adjacent Mn(II) centres, generating a polymeric chain running...

This review summarizes the literature regarding long-term adverse effects of proton pump inhibitors (PPIs). A PubMed search (1966 to February 2013) for English language studies was conducted using key terms PPI: omeprazole, esomeprazole, pantoprazole, lansoprazole, dexlansoprazole, rabeprazole, pneumonia, Clostridium difficile, osteoporosis, risk of fractures, thrombocytopenia, rhabdomyolysis, ...

In the title complex, [ZnCl2(C10H9N5)2], the Zn(II) ion is coordinated by two N atoms from two 2-[(1H-1,2,4-triazol-1-yl)meth-yl]-1H-benzimidazole (tmb) ligands and by two chloride ligands in a slightly distorted tetra-hedral geometry. In the tmb ligands, the benzimidazole rings systems are essentially planar, with maximum deviations from the mean plane of 0.021 (3) and 0.030 (3) Å, and form di...

The title compound, [Cd(2)(NCS)(4)(C(8)H(8)N(2))(4)], is a centrosymmetric dinuclear cadmium(II) complex in which each two metal ions are linked by a pair of thio-cyanate N:S-bridges. Two 2-methyl-benzimidazole N-atom donors and one terminal thio-cyanate N atom complete a highly distorted square-pyramidal geometry around the Cd atom. In the crystal structure, two N-H⋯S hydrogen-bonding inter-ac...

Herpesvirus DNA packaging involves binding and cleavage of DNA containing the specific DNA-packaging motifs. Here we report a first characterization of the terminase subunits pUL56 and pUL89 of human cytomegalovirus (HCMV). Both gene products were shown to have comparable nuclease activities in vitro. Under limiting protein concentrations the nuclease activity is enhanced by interaction of pUL5...