Background: Based on the radiation biology model of prostate cancer, hypofractionated radiotherapy can improve the treatment outcomes without increasing toxicity. Although hypofractionated radiotherapy is implemented over a short period of time, it is more convenient and cheaper compared with conventional fractionated treatment. The aim of this study was to investigate the early toxicity of mod...

Jason A. Scott, Litao Xie, Hui Li, Weiwei Li, Julie B. He, Philip N. Sanders, A. Brent Carter, Johannes Backs, Mark E. Anderson, and Isabella M. Grumbach Departments of Medicine, Molecular Physiology and Biophysics, Free Radical and Radiation Biology Program, Radiation Oncology, Carver College of Medicine, University of Iowa; Iowa City VA Medical Center, Iowa City, Iowa; and Department of Inter...

Radiation biology is being transformed by the implementation of small animal image-guided precision radiotherapy into pre-clinical research programmes worldwide. We report on the current status and developments of the small animal radiotherapy field, suggest criteria for the design and execution of effective studies and contend that this powerful emerging technology, used in combination with re...

*Correspondence: Athanassios Vassilopoulos, Department of Radiation Oncology, Laboratory for Molecular Cancer Biology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA, Tel: 312503-0727; E-mail: athanasios.vasilopoulos@ northwestern.edu Received Date: 19 May 2017 Accepted Date: 01 Jun 2017 Published Date: 10 Jun 2017 Citation: Ch...

Dose Escalation, Not “New Biology,” Can Account for the Efficacy of Stereotactic Body Radiation Therapy With Non-Small Cell Lung Cancer J. Martin Brown, PhD,* David J. Brenner, PhD,y and David J. Carlson, PhDz *Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California; yCenter for Radiological Research, Columbia University Medical Center, New York, New York;...

Radiotherapy has been an integral treatment modality for cancer. The field arose from and progressed through innovations in physics, engineering, and biology. The evolution of radiation oncology will rely on the continued adoption of advances from other fields. A new area of science that possesses the ability to impact radiation oncology is nanomedicine. Materials on the nanoscale provide many ...

European Synchrotron Radiation Facility, BP 181, 38043 Grenoble, France (L.A.L., C.Z., S.A., J.T., S.M.); Department of Biology, Washington University, St. Louis, Missouri 63130 (S.G.L., J.M.J.); Donald Danforth Plant Science Center, St. Louis, Missouri 63132 (Y.W.); Nestlé Research and Development, Notre-Dame d’Oé, BP 49416, Tours 37097, France (J.G.M.); Unit of Virus Host-Cell Interactions, U...

Conventional wisdom would have one believe that melanoma is a highly radioresistant tumor, perhaps even “radiation proof.” This reputation developed as a result of a combination of factors. First, early in vitro studies of melanoma radio-biology suggested that melanoma cells displayed enhanced postradiation survival vs comparison cells.[1] Second, clinical use of radiation therapy for melanoma ...

UV-B radiation (UV-B: 280-320 nm) can cause a wide range of responses in plant cells. These responses depend on the perception of the UV-B radiation, signal transduction mechanisms and modification of gene expression. Studies over the last ten years have revealed a complex molecular response of plant cells to UV-B radiation. Specific changes in gene activity take place and a number of signal tr...

The number of people that receive exposure to ionizing radiation (IR) via occupational, diagnostic, or treatment-related modalities is progressively rising. It is now accepted that the negative consequences of radiation exposure are not isolated to exposed cells or individuals. Exposure to IR can induce genome instability in the germline, and is further associated with transgenerational genomic...