Introduction: The role of radiotherapy as a part of cancer management increases every year around the world. Thus, Radiation protection in the design of radiotherapy rooms are of great importance.   Materials and Methods: In present study using Monte Carlo method, MCNPX code, fourteen types of developed high density concretes with densities ranging from 2.45 ...

Local recurrence and distant metastasis frequently occur after radiation therapy for cancer and can be fatal. Evidence obtained from radiochemical and radiobiological studies has revealed these problems to be caused, at least in part, by a tumor-specific microenvironment, hypoxia. Moreover, a transcription factor, hypoxia-inducible factor 1 (HIF-1), was identified as pivotal to hypoxia-mediated...

Introduction: Glioma is the most common type of primary brain tumor that originates from glial tissues. These types of tumors have a high degree of malignancy and poor prognosis and low survival rates. The evaluation response to treatment is essential to decide whether present treatment is adequate or need for alternative therapy. The aim of this study was to evaluate the resp...

PURPOSE/OBJECTIVES Current Radiation Therapy Oncology Group (RTOG) guidelines for pelvic radiation therapy are based on general anatomic boundaries. Sentinel lymph node (SLN) imaging can identify potential sites of lymph node involvement. We sought to determine how tailored radiation therapy fields for prostate cancer would compare to standard RTOG-based fields. Such individualized radiation th...

PURPOSE We performed a retrospective cohort study using propensity score analysis to calculate long-term survival in patients with prostate cancer with Gleason score 8 or greater who were treated with conservative therapy, radiation therapy and radical prostatectomy. MATERIALS AND METHODS Between January 1, 1980 and December 31, 1997, 3,159 patients in the Henry Ford Health System were diagno...

Evidence-based medicine integrates the best available data in decision making, with the goal of minimizing physicians' and patients' subjectivity. In 2006, the American Society of Clinical Oncology edited clinical practice guidelines for the use of larynx preservation strategies. The objective of this review was to evaluate the current levels of evidence for glottic squamous cell carcinoma. Cur...

Although a large number of men above age 50 will develop prostate cancer, only in a small proportion of patients will their tumor become aggressive. For the majority of men with non-aggressive tumors, one can delay invasive treatment until the tumor becomes aggressive (watchful waiting). It is essential to precisely characterize the tumor. This can be achieved with multimodality MRI. With nomog...

OBJECTIVES The aim of the study was to estimate acute and late complications of radiation therapy in primary invasive vaginal carcinoma (PIVC) patients. MATERIAL AND METHODS The analysis was performed for the group of 152 PIVC patients given radical radiotherapy in the Krakow Branch of Centre of Oncology during the 1967-2005 period. Twenty five (16.5%) patients in I stage with primary tumour ...

Radiation therapy provides a means to kill large numbers of cancer cells in a controlled location resulting in the release of tumor-specific antigens and endogenous adjuvants. However, by activating pathways involved in apoptotic cell recognition and phagocytosis, irradiated cancer cells engender suppressive phenotypes in macrophages. We demonstrate that the macrophage-specific phagocytic recep...