There are numerous imaging tests for diagnosing musculoskeletal infection. Radiographs are routinely performed, because even when not diagnostic, they provide an anatomic overview of the region of interest that could influence subsequent procedure selection and interpretation. Magnetic resonance imaging is sensitive and provides superb anatomic detail. Bone scintigraphy accurately diagnoses ost...

PURPOSE Epidermal growth factor receptors (EGFR) play an important role in tumorigenesis and, therefore, have become targets for new molecular therapies. Here, we use a "cocktail" of optically labeled monoclonal antibodies directed against EGFR-1 (HER1) and EGFR-2 (HER2) to distinguish tumors by their cell surface expression profiles. EXPERIMENTAL DESIGN In vivo imaging experiments were done ...

OBJECTIVE Adenosine, which has been used for a myocardial perfusion scan, shows rapid clearance from blood because of its short half-life of <10 seconds. This simulation study evaluates influences of modes of radionuclide injection on ventricular adenosine concentration when one intravenous injection line is used. METHODS Assuming that radionuclide injection is a unit impulse, time-activity c...

Radioactive agents currently available for imaging infection by gamma scintigraphy do so by identifying inflammation in response to the infection, and are therefore non-specific in so far as they are unable to distinguish between infective and non-infective inflammation. The term ‘infection imaging’ is therefore generally synonymous with ‘inflammation imaging’. This article will briefly review ...

Abstract Radiopharmaceuticals can be used for targetspecific functional diagnostics, such as PET or SPECT imaging, radionuclide therapy of diseased tissue, depending on the incorporated radionuclide. Following initial in vitro testing, radiopharmaceutical candidates are usually further characterized small animals. Since reduction, replacement and refinement (3R) animal testing is a central prec...

The epidermal growth factor receptor (EGFR) is overexpressed in a number of malignant tumors and is a molecular target for several specific anticancer antibodies and tyrosine kinase inhibitors. The overexpression of EGFR is a predictive biomarker for response to several therapy regimens. Radionuclide molecular imaging might enable detection of EGFR overexpression by a non-invasive procedure and...