Purpose: Analysis of modern approaches to dosimetric support radionuclide therapy at the technological stages planning, hospitalization in a hospital and evaluation treatment eծectiveness. Material methods: A comparative analysis methodological specifics with introduction radiopharmaceuticals into body conventional radiation using sealed sources ionizing was carried out. Two methodically differ...

Background Familial amyloid polyneuropathy (FAP) is a severe hereditary disease, due to production by the liver of a genetic variant transthyretin (TTR) resulting in tissue amyloid deposits. Cardiac involvement is of major prognostic value. Diphosphonate scintigraphy has been proposed as a diagnostic tool for TTR-related cardiac amyloidosis, but there is no consensus on the optimal radiopharmac...

Although [18F] 2-fluoro-2-deoxy-D-glucose (FDG) is the most widely used radiopharmaceutical the world over, it is not the ideal tracer for brain imaging, owing to its high physiological cortical uptake and lack of specificity. This has paved the way for the introduction of several novel radiotracers, each with their own inherent strengths and limitations. We present the insights gained from the...

ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high p...

By continuous monitoring of a solid meal labelled with a radiopharmaceutical it has been possible to determine the effects of drugs on gastric emptying and motility during a single study. Predictably hyoscine delayed, and bethanechol increased, the rate of gastric emptying. Pentagastrin initially produced marked antral activity resulting in a physiological stricture and subsequent delay in the ...

Science, like the universe itself, is ever expanding. The fields of biochemistry, physiology and pharmacology are rapidly growing, and radiopharmaceutical chemistry is no exception. In a recent Editorial Dr William C. Eckelman briefly reviewed the current status of radiopharmaceutical development (Eckelman, 1991). The ballots are out and returns are mixed. Radiopharmaceutical chemists have made...

Although [18F] 2-fluoro-2-deoxy-D-glucose (FDG) is the most widely used radiopharmaceutical the world over, it is not the ideal tracer for brain imaging, owing to its high physiological cortical uptake and lack of specificity. This has paved the way for the introduction of several novel radiotracers, each with their own inherent strengths and limitations. We present the insights gained from the...

Article history: Received 5 August 2016 Accepted 5 August 2016 Available online 9 August 2016 tomography (PET). Brain function, which reflects the amount of ‘activity’ that the brain generates, can be measured via its blood perfusion and/or metabolism by using PET with intravenous injection of a radiopharmaceutical tracer such as H2O (Fox et al., 1984). Active brain regions have a higher need o...

Sodium fluoride ([18F]NaF) is a PET radiopharmaceutical for vizualization of the skeletal system and microcalcification. In originally designed in-house method, [18F]NaF recovered in aqueous solution after cyclotron irradiation, sterilized by passage through 0.22 µm sterile filter dispensed under aseptic conditions. To ensure microbiological safety drugs produced conditions, validation procedur...