Treatment with recombinant human erythropoietin (rhEPO) improves anaemia in approximately 20% of the patients with myelodysplastic syndromes (MDS). Recent reports suggest that a combination treatment with rhEPO plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) given for up to 18 weeks may result in a higher erythroid response rate than with rhEPO alone. We investigated the ...

M yelodysplasia (MDS) is a clonal hematopoietic malignancy as stubborn in revealing its pathogenesis as it is in responding to treatment. The disease presents with cytopenia of any or all of the three hematopoietic lineages (red blood cells, platelets, and white blood cells), manifesting clinically as fatigue, bleeding, and infectious disorders. While the disease occurs in only five per 100,000...

A 75-year-old male was admitted for investigation of acute kidney injury. His medical history was significant for hypothyroidism and transfusion-dependent myelodysplastic syndrome. A bone marrow biopsy 1 month prior to admission had categorized him as having refractory anaemia with excess blasts (RAEB) Stage-II. His medications included thyroxine, cholecalciferol and the cytotoxic agent azacita...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Successful re-treatment with azacitidine in a patient with low blast count AML transformed from MDS after suspension of this agent TO THE EDITOR: The treatment approach to acute myeloid leukemia (AML) transformed from high-risk myelodys-plastic syndrome (MDS...

BACKGROUND Matrix metalloproteinase -2 (gelatinase-A, Mr 72,000 type IV collagenase, MMP-2) and -9 (gelatinase-B, Mr 92,000 type IV collagenase, MMP-9) are key molecules that play roles in tumor growth, invasion, tissue remodeling, metastasis and stem-cell regulation by digesting extracellular matrix barriers. MMP-2 and -9 are well known to impact on solid cancer susceptibility, whereas, in hem...

distinct clusters (#3 and #11) highly enriched for SF mutations and RAEB/AML-LBC phenotypes with significantly lower bone marrow blast counts, together with known clusters characterized by the presence of t(8;21), inv(16), t(15;17), and CEBPA mutations. 9,10 Interestingly, whole exome sequencing of 14 cases with SF mutations within the 2 clusters revealed mutations in 3 genes implicated in RNA ...

Objective: To report a rare case of brucellosis with myelodysplastic syndrome (MDS). Clinical Presentation and Intervention: A 70-year-old woman presented with pancytopenia and fever of unknown origin (FUO). The initial diagnosis was brucellosis; the woman was treated with doxycycline and rifampin against Brucella melitensis but was later diagnosed as suffering from MDS. She was immediately tra...

Objective: To report a rare case of brucellosis with myelodysplastic syndrome (MDS). Clinical Presentation and Intervention: A 70-year-old woman presented with pancytopenia and fever of unknown origin (FUO). The initial diagnosis was brucellosis; the woman was treated with doxycycline and rifampin against Brucella melitensis but was later diagnosed as suffering from MDS. She was immediately tra...