نتایج جستجو برای: randomized placebo controlled trial
تعداد نتایج: 687100 فیلتر نتایج به سال:
background: organic nitrates relax all kinds of smooth muscle , not only vascular smooth muscle , a fact that has allowed the use of these drugs to treat many different aliments. objective.-the purpuse of this study was to examine prosepectively benefical effects , if any, of sublingual nitroglycerin on the pain of renal colic. design.- prospective , randomised , double blind, placebo- contoled...
Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the us...
OBJECTIVE Ciclosporin and MTX are used in idiopathic inflammatory myopathies (DM and PM) when patients incompletely respond to glucocorticoids. Their effectiveness is unproved in randomized controlled trials (RCTs). We evaluated their benefits in a placebo-controlled factorial RCT. METHODS A 56-week multicentre factorial-design double-blind placebo-controlled RCT compared steroids alone, MTX ...
The number and temporal distribution of follow-up assessments during a clinical trial is a critical factor which may influence the outcome as well as the overall cost of a trial. Therefore, we aimed to examine whether the overall and differential frequency of study observations during the course of a clinical trial affects the risk ratio (RR) of responding to antidepressants vs. placebo, specif...
Abstract Background Patients with major depressive disorder (MDD) often do not respond to antidepressant (ADT) monotherapy alone and may require adjunctive treatment provide adequate symptom relief. Cariprazine (CAR) is a dopamine D 3 -preferring /D 2 serotonin 5-HT 1A receptor partial agonist approved treat adults schizophrenia manic, mixed, or episodes of bipolar I disorder. Post hoc analysis...
Objective: This study’s purpose was to verify the PAKU-PAKU KOUBO-KUN (PPKK) containing yeast and mulberry extract concentrate’s effects on suppressing elevated postprandial blood glucose (PBG).Methods: Two randomized, placebo-controlled, crossover studies (TRIAL-1 TRIAL-2) were conducted. Both included healthy Japanese adults with a maximum PBG concentration (Cmax) in range of 140–199 mg/dL. S...
AIM To test whether melatonin reduces oxidative and inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction. MATERIALS AND METHODS Twenty pigs were randomized to receive a total dosage of 200 mg (0.4 mg/ml) of melatonin, or placebo immediately prior to reperfusion of a coronary artery balloon occlusion in a randomized, observer-blinded, placebo-controlled trial....
PCN3 RANDOMIZED, PLACEBO, CONTROLLED, DOUBLE-BLIND TRIAL OF MELATONIN IN CHOLANGIOCARCINOMA PATIENTS
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