To the Editor: The recent article published in Circulation by Krahn et al1 underlines the usefulness of implantable loop recorders in the investigation of unexplained syncope. Patients with unexplained syncope were randomized to a “conventional” investigation strategy or to a “prolonged monitoring” strategy with an implantable loop recorder, with the latter strategy yielding a higher diagnostic...

Clinical effect of TESSYS technique under spinal endoscopy combined with drug therapy in patients lumbar disc herniation and its on quality life serum inflammatory factors: results a randomized trial

Randomized controlled trial (RCT) is generally considered to be one of the strongest study designs because the results it generates, have minimum bias and avoids confounders by virtue of the randomization and blinding technique which it employs. It has the potential to generate a Level B evidence on its own or even a Level A evidence when a pooled meta-analysis or a systematic review of several...

EACH YEAR, MORE THAN 730 000 Americans experience a new or recurrent stroke, with resulting direct and indirect health care costs totaling $35 billion and $21.8 billion, respectively. Up to 85% of the approximately 566 000 stroke survivors experience hemiparesis, resulting in impairment of an upper extremity immediately after stroke, and between 55% and 75% of survivors continue to experience u...