Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase that requires two cofactor Mg(2+) ions for catalysis in regulating many important cellular signals. Experimentally, Li(+) is a competitive inhibitor of GSK3β relative to Mg(2+), while this mechanism is not experienced with other group I metal ions. Herein, we use native Mg(2)(2+)-Mg(1)(2+) GSK3β and its Mg(2)(2+)-M(1)(+) (M = Li, ...

OBJECTIVE The Na content of bread is one of the most common targets of initiatives to reduce Na intake worldwide. Assessing the Na content of staple foods is of major relevance in Mozambique, given the high burden of hypertension in this setting. We aimed to estimate the Na content of white bread available in different bakeries and markets in Maputo. DESIGN A cross-sectional study of the Na c...

OBJECTIVE THE AIM OF THIS STUDY WAS TO EVALUATE THE MINERAL CONTENT OF DENTIN IRRADIATION WITH ERBIUM: yttrium-aliminum-garnet (Er:YAG), Neodmiyum:yttrium-aliminum garnet (Nd:YAG) and potassium titanium phosphate (KTP) laser used for in the treatment of dentin hypersensitivity. METHODS Six extracted wisdom, unerupted molar teeth were used in this study. The enamel of the teeth was removed wit...

The effects of intragastric administration of the prototypical benzodiazepine (BDZ) anxiolytic drug chlordiazepoxide (CDP) and the non-BDZ anxiolytic agent buspirone (BUSP) on basal and stress-elevated plasma noradrenaline (NA), adrenaline (A) and corticosterone (CS) contents were investigated. Acute dosing of CDP (1-27 mg/kg) produced dose-related increases in basal CS secretion but was withou...

The effects of the classical benzodiazepine (BDZ) anxiolytic drug chlordiazepoxide (CDP) and the non-BDZ anxiolytic agent buspirone (BUSP) on basal and stress-induced plasma noradrenaline (NA), adrenaline (A) and corticosterone (CS) release were investigated. Male Wistar rats provided with a permanent heart catheter and a permanent stomach catheter were used. Placement of rats into an unfamilia...

The causes of central nervous system (CNS) dysfunction in uremia are not well known and are not completely reversed by dialysis. This problem was investigated in synaptosomes, which are membrane vesicles from synaptic junctions in the brain. We measured Na uptake under conditions of control, veratridine stimulation, and tetrodotoxin inhibition, in synaptosomes from normal and acutely uremic (bl...

Salt stress is one of the most chalanging abiotic stresses affecting natural productivity and causing significant croplosses worldwide. A greenhouse experiment was conducted to evaluate the response of two alfalfa cultivars (Bamiand Hamedani) to 6 levels of salinity (0 as control, 25, 50, 75, 100, 125 mM NaCl) at the College of Agriculture,Shiraz University, Shiraz, Iran in 2008. Plant dry weig...

Salinity is an environmental stress that limits growth and development in plants. Due to high salinity in Khuzestan soils it is necessary to identify cultivars with appropriate yield that are compatible with Khuzestan conditions. This experiment was done to evaluate three rice cultivars for salinity tolerance at seedling stage by measuring the absorption of sodium and potassium ions and the rat...