Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam. Despite a modest LET (~19 keV/μm), antiprot...

Tritium RBE/Tritiated Water/CFUs/CFUc The acute effects on hematopoietic tissue in mice of a single administration of tritiated water were compared with the effects of exposure to 6OCo gamma radiation. The activity of tritium in the bone marrow was measured directly using a sample oxidizer and the absorbed dose was calculated from the amount of activity of tritium in it. The number of nucleated...

introduction: heavy ions are nucleus of elements of iron, argon, carbon and neon that all carry positive electrical charges. for these particles to be useful in radiotherapy they need to accelerated to high energy by more than thousand mega volts. also the cosmic environment is considered to be a complicated mixture of highly energetic photons and heavy ions such as iron. therefore, the health ...

free radicals involved in a number of diseases due to the oxidative damage to dna, lipids, and proteins and which can result in failure of cellular functions. dried plant bulbs and leaves methanolic and ethanolic extracts were prepared. total antioxidant activities of the methanolic extracts of romulea ramiflora and gagea fibrosa were determined using β-caroten-linoleic acid assay. romulea-bulb...

From cellular radiosensitivity parameters and theoretical particle-energy spectra in tissue, of the secondary particles from neutron and negative pion irradiations, RBE-Dose relations have been calculated. The theoretical results are compared with clinical and radiobiological data for normal tissue, tumours and cells in culture. Formulae for calculation, cellular parameters and the needed prope...

The rigid-block equilibrium (RBE) method uses a penalty formulation to measure structural infeasibility or guide the design of stable discrete-element assemblies from unstable geometry. However, RBE is purely force-based formulation, and it incorrectly describes stability when complex interface geometries are involved. To overcome this issue, paper introduces coupled analysis (CRA) method, more...

This study investigated possible differences using the same stretch-shortening exercise (SSE) protocol on generally accepted monitoring markers (dependent variables: changes in creatine kinase, muscle soreness, and voluntary and electrically evoked torque) in males across three lifespan stages (childhood versus adulthood versus old age). The protocol consisted of 100 intermittent (30 s interval...

Cholangiocarcinoma (CCA) is a common carcinoma of the liver, and the majority of patients with CCA have a poor prognosis due to the lack of effective nonsurgical therapies in addition to its rapid progression and inoperability at the time of diagnosis. The development of novel nonsurgical therapeutics that efficiently target CCA could significantly improve the prognosis for patients presenting ...

For some temperatures of atmospheric interest from 200 to 298 K, the self-broadening coefficients of OCS-OCS and HCN-HCN collisional systems, at different strengths of electrostatic interactions, were calculated respectively for ν1 and ν2 bands for a wide range of rotational quantum numbers J. In particular, we have considered some lines that were not studied previously. We have employed the ap...