BACKGROUND Lymphadenopathy (LAP) may be the first symptom of many diseases. We aimed to investigate peripheral LAP results taken by excisional biopsy. METHODS Histopathological examination of 185 lymph node biopsy specimens were evaluated between January 2009 and April 2015 in Istanbul Private Ekin Pathology Laboratory, retrospectively. RESULTS The average age of patients ranged from 1 to 8...

The brains of most demented patients show at autopsy the lesions of Alzheimer's disease (AD). However, the brains of other demented patients show either no morphological changes or lesions distinct from those of AD. We report clinicopathological studies on two diseases in this latter group. The study of these diseases can improve our understanding of AD. Pick's disease is characterized by demen...

A wide variety of noninfectious lesions have been identified in association with HIV infection. Many hematolymphoid lesions are possible in this patient group, both reactive and neoplastic. Epidemiologic data suggests that lymphoid malignancies are among the most common neoplasms in patients with HIV. We present a selective case series assembled over a 5-year period from the relatively low HIV-...

Recent immunohistological and imaging studies emphasize the crucial role of axonal injury in determining the extent of permanent neurological deficits in patients with multiple sclerosis. We have recently shown that human immune cells are capable of producing the neurotrophin brain-derived neurotrophic factor (BDNF), which can prevent axonal and neuronal damage after various pathological insult...

Inflammatory and reactive lesions of the breast are relatively uncommon among benign breast lesions and can be the source of an abnormality on imaging. Such lesions can simulate a malignant process, based on both clinical and radiographic findings, and core biopsy is often performed to rule out malignancy. Furthermore, some inflammatory processes can mimic carcinoma or other malignancy microsco...

Background: The pattern of distribution of skin diseases remains one of the most elusive problems in dermatology, particularly when multiple pathologies are involved and coexistence of patterns is present. Most skin diseases show a predilection for certain body areas and are located in characteristic patterns. Many dermatoses exhibit lesions in a segmental fashion concomitantly with disseminate...

Acne and rosacea are both highly prevalent inflammatory skin diseases that characterized by erythema, papules, pustules, primarily involving the pilosebaceous units of face, yet with distinct mechanisms disease pathogenesis. Here, we used single-cell RNA-sequencing (scRNA-seq, n=22) spatial imaging (CosMx, n=4) to compare gene expression individual cells in acne vs. lesions elucidate pathways p...

Lymph node biopsy and histopathological examination (HPE) is an extremely important investigation helpful in differentiating between reactive and neoplastic states including lymphomas, sarcomas, histiocytosis and leukemias. Lymph node biopsy is also helpful in differentiating between primary and secondary malignant lesions of the lymph node. The present study was carried out in the Department o...

Intragastric administration of 6% H2O2 induces gastric mucosal hemorrhagic lesions in rats. Intraperitoneal administration of rebamipide at 10 to 100 mg/kg dose-dependently prevented the H2O2-induced mucosal lesions. The fact that cimetidine, ranitidine and omeprazole could not prevent the gastric mucosa from developing H2O2-induced lesions indicates that acid secretion might not be the main ca...

Genomic integrity is constantly challenged by DNA damaging agents such as reactive oxygen species (ROS). Consequently, DNA damage can compromise the fidelity and efficiency of essential DNA metabolic processes, including replication and transcription, which may contribute significantly to the etiology of many human diseases. Here, we review one family of DNA lesions, the epimeric 2-deoxyribose ...