Background and Purpose Dopamine agonists targeting D2 receptor have been used for decades in treating pituitary adenomas. There has little clear evidence implicating the canonical G protein signalling as mechanism by which suppresses growth of tumours. We hypothesize that ?-arrestin2-dependent is molecular dictating inhibitory effects on tumour growth. Experimental Approach The involvement ?-ar...

C-reactive protein (CRP) is an acute phase serum protein that shares several functions with immunoglobulin (Ig)G including complement activation and binding to receptors on monocytes and neutrophils. The identity of the receptor for CRP has been the target of extensive research. We previously determined that CRP binds to the high affinity receptor for IgG, FcgammaRI (CD64). However, this intera...

Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alzheimer's disease (AD). Activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progressio...

A truncated structural protein of hepatitis E virus (HEV), p239, occurs as 23 nm particles consisting of partial homodimers. As the latter resemble the HEV capsomere structurally and antigenically, it was postulated that the recombinant protein may serve as a probe for the HEV receptor. This hypothesis was supported by findings that purified p239 bound and penetrated different cell lines that a...

Inflammatory processes are increasingly recognized as important participants in the pathophysiology of hypertension and cardiovascular disease. Angiotensin II may be to a large degree responsible for triggering vascular inflammation by inducing oxidative stress, resulting in up-regulation of inflammatory mediators. Inflammatory markers such as C-reactive protein are increased in the blood of pa...

ACPA: Anti-Citrullinated Protein Antibody; ACR: American College of Rheumatology; APRIL: A Proliferation-Inducing Ligand; BAFFR: B Cell Activating Factor Receptor; BLyS: B-lymphocyte Stimulator; BTK: Bruton’s Tyrosine Kinase; CRP: C-Reactive Protein; DMARDs: Disease-Modifying Antirheumatic Drugs; ESR: Erythrocyte Sedimentation Rate; EULAR: European League Against Rheumatism; FDA: Food and Drug ...

In this review, we summarize advances in our understanding of redox-sensitive mechanisms that regulate adipogenesis. Current evidence indicates that reactive oxygen species may act to promote both the initiation of adipocyte lineage commitment of precursor or stem cells, and the terminal differentiation of preadipocytes to mature adipose cells. These can involve redox regulation of pathways med...