Calcium gluconate production by Aspergillus niger was investigated in shake flask, rolling shaker, air-lift reactor and stirred reactor. Growth pattern of the organism and fermentation conditions determined the yield of the product. High calcium gluconate production was achieved in air-lift reactor with pellet form of cell growth at moderate specific growth rate and biomass concentration. In an...

Cell Culture Bioreactors Basic Types of Bioreactors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 Stirred Tank (Well Mixed) vs. Tubular Reactor (Plug Flow) . . . . . . . . . . . . . . . . . 3 Segregated Bioreactors (Dead Zone Present) Compartmentalized Bioreactors . . 4 Implication When Growth or Reaction Occurs in the Reactor . . . . . ....

Gel-free proteomics has emerged as a complement to conventional gel-based proteomics. Gel-free approaches focus on peptide or protein fractionation, but they do not address the efficiency of protein processing. We report the development of a microfluidic proteomic reactor that greatly simplifies the processing of complex proteomic samples by combining multiple proteomic steps. Rapid extraction ...

A system of softwares was developed in order to aid chemical reactor operation and design, as a tool to define operational policies and support process engineers. A C++ software, using artificial intelligence techniques, acts as an Expert System, guiding the user throughout reactor simulation and providing results in an easily comprehensible form. A Fortran software was used to simulate a react...

This paper provides an introduction to the reactor analysis capabilities of the nuclear power reactor simulation tools that are being developed as part of the U.S. Department of Energy’s Nuclear Energy Advanced Modeling and Simulation (NEAMS) Toolkit. The NEAMS Toolkit is an integrated suite of multi-physics simulation tools which leverage high-performance computing to reduce uncertainty in the...

This paper presents the formulation of a controller for a Catalytic Flow Reversal Reactor (CFRR) with heat extraction. The controller is based on the Model Predictive Control (MPC) concept. The MPC scheme uses a model that assumes plug flow and neglects radial gradients in the reactor but accounts for the two phases within the reactor. The prediction of the future output behavior from the model...

The Tennessee Eastman chemical process is a well-defined simulation of a chemical process that has been commonly used in process control research. As chemical process plants are getting more complex, the pressure on chemical engineers to develop accurate models for monitoring and control purposes is increased. In this paper, we explore the idea of using Genetic Programming (GP) technique to mod...

India is building a 500 MWe Prototype Fast Breeder Reactor, which is scheduled to be operational by 2010. India has refused to accept international safeguards on this facility, raising concerns that the plutonium produced in its uranium blankets might be used to make nuclear weapons. Based on neutronics calculations for a detailed threedimensional model of the reactor, we estimate that up to 14...

The bubble effectiveness in liquid phase cylohexane non-catalytic oxidation process is discussed in this paper. Then the bubble effectiveness and a new proposed kinetic model are used in the mathematical model of the industrial reactor for the cyclohexane non-catalytic oxidation process. Furthermore, simulation and optimization based on this reactor model are carried out. The results of sim...