The aim of this Phase I clinical trial was to assess the feasibility and safety of capecitabine-based preoperative chemoradiotherapy (CRT) combined with bevacizumab and to determine the optimal capecitabine dose for Japanese patients with locally advanced rectal cancer. Patients with cT3/T4 rectal cancer were eligible. Bevacizumab was administered at 5 mg/kg intravenously on Days 1, 15 and 29. ...

Oral formulations of 5-aminosalicylic acid (mesalazine) appear less toxic than sulphasalazine. We have therefore compared sulphasalazine, low dose mesalazine and high dose mesalazine in the treatment of mild to moderate relapse of ulcerative colitis. Sixty one patients (32 men, aged 20-78 years) were randomly allocated to sulphasalazine 2 g daily, mesalazine 800 mg daily, or mesalazine 2.4 g da...

BACKGROUND Dearterialization should reduce arterial overflow to haemorrhoids. The purpose of this study was to assess the topography of haemorrhoidal arteries. METHODS Fifty patients with haemorrhoidal disease were studied. Using endorectal ultrasonography, six sectors were identified within the lower rectal circumference. Starting from the highest level (6 cm above the anorectal junction), t...

Watanabe T.T.N., Zlotowski P., Oliveira L.G.S., Rolim V.R., Juffo G.D., Gomes M.J.P., Snel G. & Driemeier D. 2011. Rectal stenosis in pigs associated with Salmonella Typhimurium and porcine circovirus type 2 (PCV2) infection. Pesquisa Veterinária Brasileira 31(6):511-515. Setor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 909...

Background: To reduce the dose to normal tissues surrounding the treated breast, a uniform magnetic field was used within a humanoid phantom in breast radiotherapy. Materials and Methods: Monte Carlo simulations were performed with GEANT4, irradiating humanoid phantoms in a magnetic field. To reconstruct phantoms, computed tomography (CT) data slices of four patients were used for the Monte Car...

In 2008 he was diagnosed with a rectal adenocarcinoma (pT3N0M0) and villous adenoma at 11 and 4 cm from the anal margin, respectively. Short-course radiotherapy (25 Gy in 5 Gy daily fractions) was administered and the patient underwent anterior rectal resection plus perianal adenoma resection. During follow-up a positron emission tomograph was performed (2011), which identified two nodules; one...

CONTEXT The serum carcinoembryonic antigen (CEA) is an important prognostic factor in colorectal cancer, however the rectum presents different routes of venous drainage, stating that the level of CEA in peripheral and mesenteric rectal tumors may be different, depending on the location of the tumor in the rectal segment. OBJECTIVE The goal of this study was to evaluate the relationship betwee...

PURPOSE The purpose of this study was to assess the dosimetric equivalence of magnetic resonance (MR)-generated synthetic CT (synCT) and simulation CT for treatment planning in radiotherapy of rectal cancer. METHODS This study was conducted on eleven patients who underwent whole-body PET/MR and PET/CT examination in a prospective IRB-approved study. For each patient synCT was generated from D...

objective: to detect whether the preoperative combined administration of rectal diclofenac and paracetamol is superior to placebo or rectal diclofenac alone for pain after abdominal hysterectomy. materials and methods: ninety female patients (american society of anesthesiologists (asa) physical status i-ii), scheduled for abdominal hysterectomy were recruited to this double blind trial and were...